Evidence map›Paper›PMID 39814200›Full record

ArticleAnnals of oncology : official journal of the European Society for Medical Oncology2025

The impact of neoadjuvant therapy in patients with left-sided resectable pancreatic cancer: an international multicenter study.

E Rangelova, T F Stoop, T M E van Ramshorst, M Ali, E A van Bodegraven, A A Javed, D Hashimoto, E Steyerberg, A Banerjee, A Jain and 166 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Annals of oncology : official journal of the European Society for Medical Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Pancreatic cancer in 2025: Have we found a solution?World journal of gastroenterology · 2025
    Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

176 authors.

E RangelovaDepartment of Upper Abdominal Surgery at Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. Electronic address: t.f.stoop@amsterdamUMC.nl.
T F StoopAmsterdam UMC, Location University of Amsterdam, Department of Surgery, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands; Division of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, USA.
T M E van RamshorstAmsterdam UMC, Location University of Amsterdam, Department of Surgery, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands; Department of Surgery, Fondazione Poliambulanza, Instituto Ospedaliero, Brescia, Italy.
M AliCancer Center Amsterdam, Amsterdam, The Netherlands; Amsterdam UMC, Location Vrije Universiteit, Department of Surgery, Amsterdam, The Netherlands.
E A van BodegravenAmsterdam UMC, Location University of Amsterdam, Department of Surgery, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands.
A A JavedAmsterdam UMC, Location University of Amsterdam, Department of Surgery, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands; Department of Surgical Oncology, Department of Surgery, New York University Medical Center, New York, USA.
D HashimotoDepartment of Surgery, Kansai Medical University, Osaka, Japan.
E SteyerbergDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
A BanerjeeHPB & Liver Transplant Unit, Royal Free Hospital, London, UK.
A JainDivision of Surgical Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
A SauvanetDepartment of HPB Surgery and Liver Transplantation, APHP Beaujon Hospital, University of Paris Cité, Clichy, France.
A SerrabloHPB Surgical Division, Miguel Servet University Hospital, Zaragoza, Spain.
A GianiDivision of Minimally-Invasive Surgical Oncology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
A GiardinoDepartment of HPB Surgery, Pederzoli Hospital, Peschiera del Garda, Peschiera, Italy.
A ZerbiHumanitas University, Department of Biomedical Sciences, Milan, Italy; Pancreatic Surgery Unit, Humanitas Clinical and Research Center, IRCCS, Milan, Italy.
A ArshadHepatopancreatobiliary Unit, University Hospitals Southampton NHS Trust, Southampton General Hospital, Southampton, UK.
A G WijmaDepartment of Surgery, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
A CorattiGeneral and Emergency Surgery Unit, Misericordia Hospital, Azienda USL Toscana Sud-Est, Grosseto, Italy.
A ZirondaDivision of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, USA.
A SocratousDepartment of Upper Abdominal Surgery at Sahlgrenska University Hospital, Gothenburg, Sweden; Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
A RojasDepartment of Surgery, NorthShore University Health System, Evanston, USA.
A HalimiDepartment of Surgery, Umeå University, Umeå, Sweden; Division of Surgery and Oncology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden.
A EjazDivision of Surgical Oncology, Department of Surgery, The Ohio State University, Columbus, USA.
A ObaDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, USA; Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo; Department of Hepatobiliary and Pancreatic Surgery, Cancer Institute Hospital Japanese Foundation for Cancer Research, Ariake, Tokyo, Japan.
B Y PatelHepatopancreatobiliary Unit, University Hospitals Southampton NHS Trust, Southampton General Hospital, Southampton, UK.
B BjörnssonDepartment of Surgery, Linköping University Hospital, Linköping, Sweden.
B N ReamesDepartment of Surgery, University of Nebraska Medical Center, Omaha, USA.
B TingstedtDepartment of Clinical Sciences Lund, Surgery, Lund University, Skåne University Hospital, Lund, Sweden.
B K P GohDepartment of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.
C Payá-LlorenteGeneral and Digestive Surgery, Hospital Doctor Peset, Valencia, Spain.
C D Del PozoGeneral and Digestive Surgery, Hospital Doctor Peset, Valencia, Spain.
C González-AbósHepatobiliopancreatic Department, Hospital Clinic de Barcelona, Barcelona, Spain.
C MedinDivision of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, USA.
C H J van EijckDepartment of Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
C de PonthaudDepartment of Hepatobiliary and Pancreatic Surgery and Liver Transplantation, AP-HP, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.
C TakishitaDepartment of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Tokyo, Japan.
C SchwablDepartment of Radiology, Medical University Innsbruck, Innsbruck, Austria.
C MånssonDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
C RicciDepartment of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy; Division of Pancreatic Surgery, IRCCS, Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy.
C A ThielsDivision of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, USA.
D DouchiDepartment of Surgery, Tohoku University, Sendai, Japan.
D L HughesDepartment of Hepatobiliary and Pancreatic Surgery, Oxford Radcliffe Hospitals NHS Foundation Trust, Oxford, UK.
D KilburnDepartment of Surgery, Flinders Medical Centre, Adelaide, Australia.
D FlankingDepartment of Upper Abdominal Surgery at Sahlgrenska University Hospital, Gothenburg, Sweden.
D KleiveDepartment of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway.
D S SilvaHEBIPA Surgery, Centro Hospitalar Universitário de Santo António, Porto, Portugal.
B H EdilDivision of Surgical Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
E PandoUniversitat Autónoma de Barcelona, Barcelona, Spain; Department of Hepato-Pancreato-Biliary and Transplant Surgery, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
E MoltzerDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
E F KauffmanDivision of General and Transplant Surgery, University of Pisa, Pisa, Italy.
E WarrenDivision of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, USA.
E BozkurtDepartment of General Surgery, Koç University School of Medicine, Istanbul, Turkey.
E SparrelidDivision of Surgery and Oncology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden.
E ThomaDepartment of General and Visceral Surgery, Ulm University Hospital, Ulm, Germany.
E VerkolfDepartment of Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
F AusaniaHepatobiliopancreatic Department, Hospital Clinic de Barcelona, Barcelona, Spain; Instituto de Investigaciones Biomédicas August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
F GiannoneDepartment of Visceral and Digestive Surgery, University Hospital of Strasbourg, Strasbourg, France.
F J HüttnerDepartment of General and Visceral Surgery, Ulm University Hospital, Ulm, Germany.
F BurdioDepartment of Surgery, Hepatobiliary and Pancreatic Unit, Hospital del Mar de Barcelona, Barcelona, Spain; Hospital del Mar Research Institute (IMIM), University Pompeu-Fabra, Barcelona, Spain.
F R SoucheOncologic & Minimally-Invasive Digestive Surgery, CHU Montpellier, University of Montpellier, Montpellier, France.
F BerrevoetDepartment of General and HPB Surgery and Liver Transplantation, Ghent University Hospital, Ghent, Belgium.
F DaamsCancer Center Amsterdam, Amsterdam, The Netherlands; Amsterdam UMC, Location Vrije Universiteit, Department of Surgery, Amsterdam, The Netherlands.
F MotoiDepartment of Surgery, Yamagata University, Yamagata, Japan.
G SalibaDivision of Surgery and Oncology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden.
G KazemierCancer Center Amsterdam, Amsterdam, The Netherlands; Amsterdam UMC, Location Vrije Universiteit, Department of Surgery, Amsterdam, The Netherlands.
G RoeyenDepartment of HPB, Endocrine and Transplantation Surgery, University Hospital Antwerp, Antwerp, Belgium.
G NappoHumanitas University, Department of Biomedical Sciences, Milan, Italy; Pancreatic Surgery Unit, Humanitas Clinical and Research Center, IRCCS, Milan, Italy.
G ButturiniDepartment of HPB Surgery, Pederzoli Hospital, Peschiera del Garda, Peschiera, Italy.
G FerrariDivision of Minimally-Invasive Surgical Oncology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
G Kito FusaiHPB & Liver Transplant Unit, Royal Free Hospital, London, UK.
G HondaDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
G SergeantDepartment of Abdominal Surgery, Jessa Hospital, Faculty of Medicine and Health Sciences, Universiteit Hasselt, Hasselt, Belgium.
H KartesziDepartment of Radiology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.
H TakamiDepartment of Gastroenterological Surgery (Surgery II), Nagoya University, Nagoya, Japan.
H SutoDepartment of Gastroenterological Surgery, Kagawa University, Kagawa, Japan.
I MatsumotoDepartment of Surgery, Kindai University, Osakasayama, Japan.
I Mora-OliverDepartment of Surgery, Liver and Pancreato-Biliary Unit, Hospital Clínico Universitario Valencia, Biomedical Research Institute, INCLIVA, Valencia, Spain.
I FrigerioDepartment of HPB Surgery, Pederzoli Hospital, Peschiera del Garda, Peschiera, Italy.
J M FabreOncologic & Minimally-Invasive Digestive Surgery, CHU Montpellier, University of Montpellier, Montpellier, France.
J ChenDepartment of Surgery, Flinders Medical Centre, Adelaide, Australia.
J G ShamDepartment of Surgery, University of Washington, Seattle, USA; Fred Hutchinson Cancer Center, Seattle, USA.
J DavideHEBIPA Surgery, Centro Hospitalar Universitário de Santo António, Porto, Portugal.
J UrdzikDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
J de MartinoDepartment of Hepatobiliary and Pancreatic Surgery and Liver Transplantation, AP-HP, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.
K NielsenDepartment of Hepatopancreatobiliary Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
K OkanoDepartment of Gastroenterological Surgery, Kagawa University, Kagawa, Japan.
K KameiDepartment of Surgery, Kindai University, Osakasayama, Japan.
K OkadaDepartment of Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
K TanakaDepartment of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Hokkaido, Japan.
K J LaboriDepartment of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
K E GoodsellDepartment of Surgery, University of Washington, Seattle, USA.
L AlbericiDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden; Department of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy.
L WebberDepartment of Upper GI Surgery, Fiona Stanley Hospital, Perth, Austria.
L KirkovOncologic & Minimally-Invasive Digestive Surgery, CHU Montpellier, University of Montpellier, Montpellier, France.
L de FrancoGeneral and Emergency Surgery Unit, Misericordia Hospital, Azienda USL Toscana Sud-Est, Grosseto, Italy.
M MiyashitaDepartment of Hepatobiliary and Pancreatic Surgery, Cancer Institute Hospital Japanese Foundation for Cancer Research, Ariake, Tokyo, Japan.
M MaglioneDepartment of Visceral, Transplant, and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
M GramelliniHumanitas University, Department of Biomedical Sciences, Milan, Italy; Pancreatic Surgery Unit, Humanitas Clinical and Research Center, IRCCS, Milan, Italy.
M RameraDepartment of Surgery, Fondazione Poliambulanza, Instituto Ospedaliero, Brescia, Italy; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
M J AmaralGeneral Surgery Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
M RamaekersDepartment of Surgery, Catharina Hospital, Eindhoven, The Netherlands.
M J TrutyDivision of Hepatobiliary and Pancreas Surgery, Mayo Clinic, Rochester, USA.
M A van DamDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
M W J StommelDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
M PetrikowskiDepartment of Surgery, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
M ImamuraDepartment of Surgery, Surgical Oncology and Science, Sapporo Medical University, Hokkaido, Japan.
M HayashiDepartment of Gastroenterological Surgery (Surgery II), Nagoya University, Nagoya, Japan.
M D'HondtDepartment of Digestive and Hepatobiliary-Pancreatic Surgery, Groeninge Hospital, Kortrijk, Belgium.
M BrunnerDepartment of Surgery, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen Nürnberg, Erlangen, Germany.
M E HoggDepartment of Surgery, NorthShore University Health System, Evanston, USA.
C ZhangDepartment of Surgery, University of Nebraska Medical Center, Omaha, USA.
M Á Suárez-MuñozHPB Surgical Unit, University Hospital Virgen de la Victoria, Málaga, Spain.
M D LuyerDepartment of Surgery, Catharina Hospital, Eindhoven, The Netherlands.
M UnnoDepartment of Surgery, Tohoku University, Sendai, Japan.
M MizumaDepartment of Surgery, Tohoku University, Sendai, Japan.
M JanotDepartment of Surgery, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
M A SahakyanThe Intervention Center, Oslo University Hospital, Rigshospitalet, Oslo, Norway.
N B JamiesonWolfson Wohl Cancer Research Centre, School of Cancer Sciences, University of Glasgow, Glasgow, UK.
O R BuschAmsterdam UMC, Location University of Amsterdam, Department of Surgery, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands.
O BilgeDepartment of General Surgery, Koç University School of Medicine, Istanbul, Turkey.
O BelyaevDepartment of Surgery, St. Josef Hospital, Ruhr University Bochum, Bochum, Germany.
O FranklinDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, USA; Department of Surgery, Umeå University, Umeå, Sweden.
P Sánchez-VelázquezDepartment of Surgery, Hepatobiliary and Pancreatic Unit, Hospital del Mar de Barcelona, Barcelona, Spain; Hospital del Mar Research Institute (IMIM), University Pompeu-Fabra, Barcelona, Spain.
P PessauxDepartment of Visceral and Digestive Surgery, University Hospital of Strasbourg, Strasbourg, France.
P S HolkaDepartment of Clinical Sciences Lund, Surgery, Lund University, Skåne University Hospital, Lund, Sweden.
P GhorbaniDivision of Surgery and Oncology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden.
R CasadeiDepartment of Internal Medicine and Surgery (DIMEC), Alma Mater Studiorum, University of Bologna, Bologna, Italy; Division of Pancreatic Surgery, IRCCS, Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy.
R SartorisDepartment of Radiology, APHP Beaujon Hospital, University of Paris Cité, Clichy, France.
R D SchulickDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, USA.
R GrützmannThe Intervention Center, Oslo University Hospital, Rigshospitalet, Oslo, Norway.
R SutcliffeDepartment of Hepatopancreatobiliary Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
R MataUniversitat Autónoma de Barcelona, Barcelona, Spain; Department of Hepato-Pancreato-Biliary and Transplant Surgery, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
R B PatelDivision of Surgical Oncology, Department of Surgery, The Ohio State University, Columbus, USA.
R TakahashiDepartment of Surgery, Yamagata University, Yamagata, Japan.
S Rodriguez FrancoDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, USA.
S S CabúsDepartment of HPB Surgery, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
S HiranoDepartment of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Hokkaido, Japan.
S GaujouxDepartment of Hepatobiliary and Pancreatic Surgery and Liver Transplantation, AP-HP, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.
S FestenDepartment of Surgery, OLVG, Amsterdam, The Netherlands.
S KozonoDepartment of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Tokyo, Japan.
S K MaithelDivision of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, USA.
S M ChaiDepartment of Anatomical Pathology, PathWest Laboratory Medicine, Perth, Australia.
S YamakiDepartment of Surgery, Kansai Medical University, Osaka, Japan.
S van LaarhovenDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands; Department of HPB Surgery, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.
J S D MieogDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.
T MurakamiDepartment of Surgery, Surgical Oncology and Science, Sapporo Medical University, Hokkaido, Japan.
T CodjiaDepartment of Digestive Surgery, Rouen University Hospital, Rouen, France.
T SumiyoshiDepartment of Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
T M KarstenDepartment of Surgery, OLVG, Amsterdam, The Netherlands.
T NakamuraDepartment of Gastroenterological Surgery II, Hokkaido University Faculty of Medicine, Hokkaido, Japan.
T SugawaraDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, USA; Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo.
U BoggiDivision of General and Transplant Surgery, University of Pisa, Pisa, Italy.
V HartmanDepartment of HPB, Endocrine and Transplantation Surgery, University Hospital Antwerp, Antwerp, Belgium.
V E de MeijerDepartment of Surgery, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
W BartholomäDepartment of Radiology, Linköping University, Linköping, Sweden.
W KwonDepartment of Surgery, Seoul National University Hospital, Seoul, Republic of Korea.
Y X KohDepartment of Hepatopancreatobiliary and Transplant Surgery, Singapore General Hospital and National Cancer Centre Singapore, Singapore, Singapore.
Y ChoDepartment of Surgery, Seoul National University Hospital, Seoul, Republic of Korea.
Y TakeyamaDepartment of Surgery, Kindai University, Osakasayama, Japan.
Y InoueDepartment of Hepatobiliary and Pancreatic Surgery, Cancer Institute Hospital Japanese Foundation for Cancer Research, Ariake, Tokyo, Japan.
Y NagakawaDepartment of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Tokyo, Japan.
Y KawamotoDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Y OmeDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Z SoonawallaDepartment of Hepatobiliary and Pancreatic Surgery, Oxford Radcliffe Hospitals NHS Foundation Trust, Oxford, UK.
K UemuraDepartment of Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
C L WolfgangDepartment of Surgical Oncology, Department of Surgery, New York University Medical Center, New York, USA.
J Y JangDepartment of Surgery, Seoul National University Hospital, Seoul, Republic of Korea.
R PadburyDepartment of Surgery, Flinders Medical Centre, Adelaide, Australia.
S SatoiDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, USA; Department of Surgery, Kansai Medical University, Osaka, Japan.
W MessersmithDivision of Medical Oncology, Department of Medicine, University of Colorado School of Medicine, Aurora, USA.
J W WilminkCancer Center Amsterdam, Amsterdam, The Netherlands; Amsterdam UMC, Location University of Amsterdam, Department of Medical Oncology, Amsterdam, The Netherlands.
M Abu HilalDepartment of HPB Surgery, Pederzoli Hospital, Peschiera del Garda, Peschiera, Italy.
M G BesselinkAmsterdam UMC, Location University of Amsterdam, Department of Surgery, Amsterdam, The Netherlands; Cancer Center Amsterdam, Amsterdam, The Netherlands.
M Del ChiaroDivision of Surgical Oncology, Department of Surgery, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, USA.
European Consortium on Minimally Invasive Pancreatic Surgery (E-MIPS)
International Consortium on Advanced Pancreatic Surgery

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeft-sided pancreatic cancer is associated with worse overall survival (OS) compared with right-sided pancreatic cancer. Although neoadjuvant therapy is currently seen as not effective in patients with resectable pancreatic cancer (RPC), current randomized trials included mostly patients with right-sided RPC. The purpose of this study was to assess the association between neoadjuvant therapy and OS in patients with left-sided RPC compared with upfront surgery. PATIENTS AND

methodsThis was an international multicenter retrospective study including consecutive patients after left-sided pancreatic resection for pathology-proven RPC, either after neoadjuvant therapy or upfront surgery in 76 centers from 18 countries on 4 continents (2013-2019). The primary endpoint was OS from diagnosis. Time-dependent Cox regression analysis was carried out to investigate the association of neoadjuvant therapy with OS, adjusting for confounders at the time of diagnosis. Adjusted OS probabilities were calculated.

resultsOverall, 2282 patients after left-sided pancreatic resection for RPC were included of whom 290 patients (13%) received neoadjuvant therapy. The most common neoadjuvant regimens were (m)FOLFIRINOX (38%) and gemcitabine-nab-paclitaxel (22%). After upfront surgery, 72% of patients received adjuvant chemotherapy, mostly a single-agent regimen (74%). Neoadjuvant therapy was associated with prolonged OS compared with upfront surgery (adjusted hazard ratio 0.69, 95% confidence interval 0.58-0.83) with an adjusted median OS of 53 versus 37 months (P = 0.0003) and adjusted 5-year OS rates of 47% versus 35% (P = 0.0001) compared with upfront surgery. Interaction analysis demonstrated a stronger effect of neoadjuvant therapy in patients with a larger tumor (P

conclusionsNeoadjuvant therapy in patients with left-sided RPC was associated with improved OS compared with upfront surgery. The impact of neoadjuvant therapy increased with larger tumor size and higher serum CA19-9 at diagnosis. Randomized controlled trials on neoadjuvant therapy specifically in patients with left-sided RPC are needed.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsNeoadjuvant TherapyPancreatectomyPancreatic NeoplasmsAdultAgedAlbuminsChemotherapy, AdjuvantDeoxycytidineFemaleFluorouracilGemcitabineHumansIrinotecanLeucovorinMale130-nm albumin-bound paclitaxelAlbuminsDeoxycytidineFluorouracilfolfirinoxGemcitabineIrinotecanLeucovorinOxaliplatinPaclitaxelCA19-9neoadjuvant therapypancreatic adenocarcinomapancreatic body/tailresectabletumor size

Identifiers

PMID39814200

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