ArticleCell chemical biology2025
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation.
Beste Mutlu, Kfir Sharabi, Jee Hyung Sohn, Bo Yuan, Pedro Latorre-Muro, Xin Qin, Jin-Seon Yook, Hua Lin, Deyang Yu, João Paulo G Camporez and 6 more
Abstract readPublished Erratum
In one paragraphArticle in Cell chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
16 authors.
Beste Mutlu
Kfir Sharabi
Jee Hyung Sohn
Bo Yuan
Pedro Latorre-Muro
Xin Qin
Jin-Seon Yook
Hua Lin
Deyang Yu
João Paulo G Camporez
Shingo Kajimura
Gerald I Shulman
Sheng Hui
Theodore M Kamenecka
Patrick R Griffin
Pere Puigserver
Funding
Yale Diabetes Research CenterP30DK045735 · NIDDK · YALE UNIVERSITY · PI GERALD I SHULMAN · 1993 to 2026
$44.0MTranscriptional Control of Mitochondrial Bioenergetic FunctionR01DK081418 · NIDDK · DANA-FARBER CANCER INST · PI PUIGSERVER, PERE · 2008 to 2021
$5.2MInsulin Signaling and Metabolic Effects through CLK2 KinaseR01DK089883 · NIDDK · DANA-FARBER CANCER INST · PI PUIGSERVER, PERE · 2011 to 2020
$3.8MYale Center for Metabolic Phenotyping in Live Models of Obesity and DiabetesU2CDK134901 · NIDDK · YALE UNIVERSITY · PI GERALD I SHULMAN · 2023 to 2026
$3.8MSmall molecules targeting hepatic glucose production and insulin resistanceR01DK117655 · NIDDK · DANA-FARBER CANCER INST · PI GRIFFIN, PATRICK ROBERT, PUIGSERVER, PERE · 2019 to 2023
$3.3MMechanism of Renal Cortical Insulin ResistanceR01DK133143 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 2022 to 2025
$2.3MCoordination of energy metabolism across individual tissues in mammalsR00DK117066 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI HUI, SHENG · 2020 to 2022
$730kMechanisms of mitochondrial-ER communication during dietary and thermal induced stressK99DK133502 · NIDDK · DANA-FARBER CANCER INST · PI LATORRE MURO, PEDRO ANTONIO · 2023 to 2024
$180kRemodeling mitochondrial cristae to rescue bioenergetic defects in mitochondrial diseaseF32GM136019 · NIGMS · DANA-FARBER CANCER INST · PI MUTLU, BESTE · 2020 to 2022
$154kNIDDK NIH HHS K99 DK133502NIDDK NIH HHS P30 DK045735NIDDK NIH HHS R00 DK117066NIDDK NIH HHS R01 DK081418NIDDK NIH HHS R01 DK089883NIDDK NIH HHS R01 DK117655NIDDK NIH HHS R01 DK133143NIDDK NIH HHS U2C DK134901NIGMS NIH HHS F32 GM136019
6 · The paper itselfAbstract
PubMed holds no abstract for this paper.
Identifiers
PMID39814023
PMCPMC11875230
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