Evidence map›Paper›PMID 39814009›Full record

ArticleNeuron2025

Dopamine D1 receptor activation in the striatum is sufficient to drive reinforcement of anteceding cortical patterns.

Nuria Vendrell-Llopis, Jonathan Read, Samantha Boggiano, Belinda Hetzler, Zisis Peitsinis, Cherise Stanley, Meike Visel, Dirk Trauner, Prashant Donthamsetti, Jose Carmena and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Big Rewards, Fast Learning.Neuroscience bulletin · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nuria Vendrell-LlopisHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Electrical and Computer Engineering, University of Alabama at Birmingham, Birmingham, AL 35233, USA. Electronic address: nvl2@uab.edu.
Jonathan ReadDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Samantha BoggianoDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37235, USA.
Belinda HetzlerDepartment of Chemistry, New York University, New York, NY 10003, USA.
Zisis PeitsinisDepartment of Chemistry, New York University, New York, NY 10003, USA.
Cherise StanleyHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Meike ViselHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Dirk TraunerDepartment of Chemistry, New York University, New York, NY 10003, USA; Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Prashant DonthamsettiDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37235, USA.
Jose CarmenaHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Stephan LammelHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Ehud Y IsacoffHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Neuroscience, University of California, Berkeley, Berkeley, CA 94720, USA; Weill Neurohub, University of California, Berkeley, Berkeley, CA 94720, USA; Molecular Biophysics and Integrated BioImaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address: ehud@berkeley.edu.

Funding

Transport Cycle and Inhibition of Human Na+-dicarboxylate Cotransporter NaDC3R01NS108151 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DANENG WANG · 2018 to 2026
$4.1M
Input-specific mechanisms of drug-evoked synaptic plasticity in the ventral tegmental areaR01DA042889 · NIDA · UNIVERSITY OF CALIFORNIA BERKELEY · PI Stephan Lammel · 2017 to 2026
$4.0M
Optical control of neuromodulatory GPCRsRF1MH123246 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD, TRAUNER, DIRK HARTWIG · 2020 to 2020
$3.3M
Optical Control of the Actin CytoskeletonR01GM126228 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI DIRK HARTWIG TRAUNER · 2018 to 2026
$2.6M
NIDA NIH HHS R01 DA042889NIGMS NIH HHS R01 GM126228NIMH NIH HHS RF1 MH123246NINDS NIH HHS R01 NS108151
6 · The paper itself

Abstract

Timed dopamine signals underlie reinforcement learning, favoring neural activity patterns that drive behaviors with positive outcomes. In the striatum, dopamine activates five dopamine receptors (D1R-D5R), which are differentially expressed in striatal neurons. However, the role of specific dopamine receptors in reinforcement is poorly understood. Using our cell-specific D1R photo-agonist, we find that D1R activation in D1-expressing neurons in the dorsomedial striatum is sufficient to reinforce preceding neural firing patterns in defined ensembles of layer 5 cortico-striatal neurons of the mouse motor cortex. The reinforcement is cumulative and time dependent, with an optimal effect when D1R activation follows the selected neural pattern after a short interval. Our results show that D1R activation in striatal neurons can selectively reinforce cortical activity patterns, independent of a behavioral outcome or a reward, crucially contributing to the fundamental mechanisms that support cognitive functions like learning, memory, and decision-making.

Indexed as

Corpus StriatumMotor CortexNeuronsReceptors, Dopamine D1Reinforcement, PsychologyAnimalsMaleMiceMice, Inbred C57BLMice, TransgenicRewardReceptors, Dopamine D1cortico-striatal-thalamocortical loopD1Rdopaminelearningmotor cortexneuroprosthetic learningreinforcementstriatum

Identifiers

PMID39814009
PMCPMC11886928

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.