Evidence map›Paper›PMID 39813991›Full record

ArticleImmunity2025

Interleukin-17 and fat: Timing is everything.

Matthew C Sinton, Olivia Shorthouse, Alice Costain, Juan F Quintana

Abstract readComment
PubMed Publisher
In one paragraph

Article in Immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Matthew C SintonLydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK; Division of Immunology, Immunity to Infection and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK. Electronic address: matthew.sinton@manchester.ac.uk.
Olivia ShorthouseLydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK; Division of Immunology, Immunity to Infection and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Alice CostainLydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK; Division of Immunology, Immunity to Infection and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Juan F QuintanaLydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK; Division of Immunology, Immunity to Infection and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK; Geoffrey Jefferson Brain Research Centre, University of Manchester, Manchester, UK. Electronic address: juan.quintana@manchester.ac.uk.

Funding

Academy of Medical Sciences SBF009/1079Wellcome Trust 221640/Z/20/ZWellcome Trust 303388/Z/23/ZWellcome Trust 309148/Z/24/Z
6 · The paper itself

Abstract

Interleukin-17 plays a major role in controlling adipose tissue homeostasis. In a recent study published in Nature, Douglas et al. demonstrate that time-of-day-dependent expression of interleukin-17 by tissue-resident innate lymphocytes in the adipose tissue drives circadian regulation of adipose tissue homeostasis and function.

Indexed as

Adipose TissueCircadian RhythmInterleukin-17AnimalsHomeostasisHumansImmunity, InnateLymphocytesMiceObesityInterleukin-17

Identifiers

PMID39813991

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.