Evidence map›Paper›PMID 39813768›Full record

ArticleTranslational oncology2025

Impact of radiotherapy on secondary lung cancer risk and survival in elderly female breast cancer survivors.

Jieming Lu, Zhimin Shen, Xiaoqing Wang, Yanhong Lin, Ziyang Han, Mingqiang Kang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jieming LuDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), China.
Zhimin ShenDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), China; Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, China; Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, China; Clinical Research Center for Thoracic Tumors of Fujian Province, China.
Xiaoqing WangDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), China.
Yanhong LinDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), China.
Ziyang HanDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), China; Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, China; Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, China; Clinical Research Center for Thoracic Tumors of Fujian Province, China. Electronic address: hanziyang99@163.com.
Mingqiang KangDepartment of Thoracic Surgery, Fujian Medical University Union Hospital, China; Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), China; Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, China; Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, China; Clinical Research Center for Thoracic Tumors of Fujian Province, China. Electronic address: mingqiang_kang@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This retrospective cohort study using SEER data from 2000 to 2020 examines the impact of radiotherapy on the risk of Secondary Primary Lung Cancer (SPLC) in 224,396 elderly female breast cancer survivors. Patients treated with radiotherapy displayed a 31 % increased SPLC risk compared to those not treated. Utilizing Cox Proportional Hazards and Poisson regression models, the study assessed various factors including age, race, and tumor characteristics. Propensity Score Matching (PSM) was employed to balance cohorts for survival analysis, which revealed that radiotherapy did not negatively impact overall survival despite the increased risk of SPLC. A nomogram was developed to aid clinical decision-making by predicting survival outcomes. The findings advocate for personalized treatment strategies and continuous monitoring to manage potential long-term adverse effects effectively, highlighting the need for a balanced approach in the treatment of breast cancer survivors.

Indexed as

Breast cancer survivorsElderly WomenRadiotherapySecondary primary lung cancerSurvival Analysis

Identifiers

PMID39813768
PMCPMC11783117

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.