Evidence map›Paper›PMID 39813627›Full record

ArticleNeurology2025

Sex Differences in Natural History and Health Outcomes Among Individuals With Tic Disorders.

Marisela E Dy-Hollins, Lori B Chibnik, Natasha A Tracy, Lisa Osiecki, Cathy L Budman, Danielle C Cath, Marco A Grados, Robert A King, Gholson J Lyon, Guy A Rouleau and 5 more

Abstract read
In one paragraph

Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Tourette syndrome.Nature reviews. Disease primers · 2026
    Review
  2. Article
  3. Article
  4. Pregnancy, Delivery, and Neonatal Outcomes in Women with Tourette Syndrome or Chronic Tic Disorder.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  5. Identifying Distinct Tourette Disorder Subtypes using Clinical Data.medRxiv : the preprint server for health sciences · 2025
    Article
  6. Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Marisela E Dy-HollinsDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-5688-324X
Lori B ChibnikDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard Medical School, Boston, MA.ORCID 0000-0001-6293-806X
Natasha A TracyDepartment of Psychiatry, Center for OCD, Anxiety and Related Disorders, University of Florida.
Lisa OsieckiDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Cathy L BudmanDepartment of Psychiatry, Northwell Health, New York, NY.
Danielle C CathDepartment of Psychiatry, University Medical Center Groningen, Rijks Universiteit Groningen, the Netherlands.
Marco A GradosDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.
Robert A KingYale Child Study Center, Yale School of Medicine, New Haven, CT.
Gholson J LyonDepartment of Human Genetics, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY.
Guy A RouleauDepartment of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.
Paul SandorDepartment of Psychiatry, University Health Network, University of Toronto, Ontario, Canada.ORCID 0000-0003-2397-0758
Harvey S SingerDepartments of Pediatrics and Neurology, Johns Hopkins Hospital Baltimore, MD; and.
Nutan SharmaDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Carol A MathewsDepartment of Psychiatry, Center for OCD, Anxiety and Related Disorders, UF Genetics Institute, University of Florida.
Jeremiah M ScharfDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Funding

Child Neurologist Career Development Program (CNCDP)K12NS098482 · NINDS · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI SCHLAGGAR, BRADLEY L · 2016 to 2025
$26.2M
NINDS NIH HHS K12 NS098482
6 · The paper itself

Abstract

objectivesTo analyze sex differences in outcomes in Tourette syndrome (TS) and Persistent Motor or Vocal tic disorders (PMVT) in the Tourette Association of America International Consortium for Genetics (TAAICG) dataset.

methodsThe relationship between sex and clinical measures was explored in 2,403 participants (N = 2,109 with TS; N = 294 with PMVT) from the TAAICG dataset using generalized estimating equation regression models, and adjusted for age and family relationships.

resultsFemale (vs male) participants with TS (25.5% of the sample) had 0.46 times lower odds of being formally diagnosed clinically with TS before the research study ( DISCUSSION: Female (vs male) participants with TS are less likely to be formally diagnosed, have later age at symptom onset, later age at diagnosis, and longer time-to-diagnosis. Female (vs male) participants with PMVT have an earlier age at symptom onset. Future research is needed to understand differences longitudinally in TS and PMVT.

Indexed as

Sex CharacteristicsTic DisordersTourette SyndromeAdolescentAdultAge of OnsetChildFemaleHumansMaleSeverity of Illness IndexYoung Adult

Identifiers

PMID39813627
PMCPMC11735146

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.