SynthesisEpidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil2025
Hormone therapy and cancer risks in transgender people: a systematic review.
Synthesis in Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Evidence-informed policies: tools for decision-making in the Brazilian Unified Health System.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify the available evidence on the risk of developing cancer in transgender people undergoing hormone therapy.
methodsThis was a rapid systematic review conducted in the PubMed, Embase, Virtual Health Library, Cochrane Library and Epistemonikos databases. Screening and data extraction were performed by independent reviewers using the Rayyan platform. Data extraction was carried out by 3 independent reviewers. We used the Joanna Briggs Institute checklists specific to cohort and case-control studies to assess the methodological quality of the included studies.
resultsFive studies were included, 4 cohort studies and 1 case-control. The risk of transgender people developing cancer while on hormone therapy was identified by 2 studies and not identified in 3 studies.
conclusionDespite studies with large sample sizes and rigorous selection criteria, the literature does not present a consensus on the association between hormone therapy and the development of cancer in transgender people.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.