ArticleScience advances2025
Axially multifocal metalens for 3D volumetric photoacoustic imaging of neuromelanin in live brain organoid.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Organoid Intelligent Morphomics: Decoding the organoid morphome through artificial intelligence from phenotypic quantification to mechanistic insight.Bioactive materials · 2027Review
- Engineering human multi-organ tissue chip niches for drug absorption, distribution, metabolism, excretion and toxicity prediction.Nature biomedical engineering · 2026Review
- Parallel multilayer photoacoustic microscopy of slide-free histology using a droplet-shaped UV beam.Science advances · 2026Article
- Label-free ultraviolet photoacoustic microscopy for multiscale structural phenotyping of epithelial morphogenesis in organoid-derived intestinal epithelial wrinkle tissue.Photoacoustics · 2026Article
- Electrically switchable dual-focus metalens for depth-extended in vivo photoacoustic imaging of ophthalmic vascular disease.Light, science & applications · 2026Article
- A Label-Free Ultraviolet Photoacoustic Microscopy Enables Nuclear Imaging and Toxicity Assessment in an Intact Brain Organoid.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Direct printing of metasurfaces using formulated optical materials.Nature protocols · 2026Review
- Ultra-sensitive wideband diffraction-grating-coupled-mode Fabry-Pérot resonators for ultrasound and photoacoustic detection.Photoacoustics · 2026Article
- Robust hybrid feature-driven on-the-fly mapping enables freehand 3D panoramic photoacoustic angiography.Light, science & applications · 2026Article
- Multiscale photoacoustic imaging of stroke in preclinical models and future directions toward clinical translation [Invited].Biomedical optics express · 2026Review
- UNIQUE: ultrasound non-destructive in-situ quantitative evaluation of stem cell spheroid deformability during differentiation into specific lineages.Microsystems & nanoengineering · 2026Article
- Deep-learning-Assisted Photoacoustic and Ultrasound Evaluation for Pre-transplant Human Liver Graft Quality and Transplant Suitability.medRxiv : the preprint server for health sciences · 2026Article
- Photoacoustic microscopy reveals deep angiogenic responses in 3D bioprinted tumor-vessel models.Microsystems & nanoengineering · 2026Article
- Review
- Article
- Organoids: technology refining, current applications and future directions.Molecular biomedicine · 2026Review
- Photoacoustic Microscopy for Multiscale Biological System Visualization and Clinical Translation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Label-free mid-infrared dichroism-sensitive photoacoustic microscopy for histostructural analysis of engineered heart tissues.Light, science & applications · 2026Article
- Inverse Design of Thermal Imaging Metalens Achieving 100° Field of View on a 4 × 4 Microbolometer Array.Micromachines · 2025Article
- Vector Vortex Beam-Enabled Edge Microscopy with Dynamic Orientation Selectivity.ACS photonics · 2025Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical resolution photoacoustic imaging of uneven samples without z-scanning is transformative for the fast analysis and diagnosis of diseases. However, current approaches to elongate the depth of field (DOF) typically imply cumbersome postprocessing procedures, bulky optical element ensembles, or substantial excitation beam side lobes. Metasurface technology allows for the phase modulation of light and the miniaturization of imaging systems to wavelength-size thickness. Here, we propose a metalens composed of submicrometer-thick titanium oxide nanopillars, which generates an elongated beam of diffraction-limited diameter with an aspect ratio of 286 and a uniform intensity throughout the DOF. The metalens enhances visualization of phantom samples with tilted surfaces compared to conventional lenses. Moreover, the volumetric imaging of neuromelanin is facilitated for depths of up to 500 micrometers within the human midbrain and forebrain organoids that are 3D biological models of human brain regions. This approach provides a miniaturized platform for neurodegenerative disease diagnosis and drug discovery.
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