Evidence map›Paper›PMID 39813348›Full record

ArticleScience advances2025

Revealing the reaction path of UVC bond rupture in cyclic disulfides with ultrafast x-ray scattering.

Lingyu Ma, Wenpeng Du, Haiwang Yong, Brian Stankus, Jennifer M Ruddock, Andrés Moreno Carrascosa, Nathan Goff, Yu Chang, Nikola Zotev, Darren Bellshaw and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Lingyu MaDepartment of Chemistry, Brown University, Providence, RI, USA.ORCID 0000-0002-2300-1132
Wenpeng DuDepartment of Chemistry, Brown University, Providence, RI, USA.ORCID 0000-0002-7857-7788
Haiwang YongDepartment of Chemistry and Biochemistry, University of California, San Diego, CA, USA.ORCID 0000-0002-5860-4259
Brian StankusDepartment of Chemistry, Western Connecticut State University, Danbury, CT, USA.
Jennifer M RuddockDepartment of Chemistry, Brown University, Providence, RI, USA.ORCID 0000-0002-5457-4443
Andrés Moreno CarrascosaPhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.ORCID 0000-0003-1045-7760
Nathan GoffDepartment of Chemistry, Brown University, Providence, RI, USA.ORCID 0009-0008-3007-0639
Yu ChangDepartment of Chemistry, Brown University, Providence, RI, USA.
Nikola ZotevPhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Darren BellshawPhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Thomas J LaneLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.ORCID 0000-0003-2627-4432
Mengning LiangLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.ORCID 0009-0003-6711-4555
Sébastien BoutetLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.ORCID 0000-0003-3928-1244
Sergio CarbajoLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.ORCID 0000-0002-5292-4470
Joseph S RobinsonLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.ORCID 0009-0001-5878-2944
Jason E KoglinLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.ORCID 0000-0001-6811-6083
Michael P MinittiLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.ORCID 0000-0002-9854-9717
Adam KirranderPhysical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.ORCID 0000-0002-3347-8137
Theis I SøllingCenter for Integrative Petroleum Research, College of Petroleum & Geosciences, King Fahd University of Petroleum & Minerals, Dhahran 31261, Saudi Arabia.
Peter M WeberDepartment of Chemistry, Brown University, Providence, RI, USA.ORCID 0000-0003-3017-336X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disulfide bonds are ubiquitous molecular motifs that influence the tertiary structure and biological functions of many proteins. Yet, it is well known that the disulfide bond is photolabile when exposed to ultraviolet C (UVC) radiation. The deep-UV-induced S─S bond fragmentation kinetics on very fast timescales are especially pivotal to fully understand the photostability and photodamage repair mechanisms in proteins. In 1,2-dithiane, the smallest saturated cyclic molecule that mimics biologically active species with S─S bonds, we investigate the photochemistry upon 200-nm excitation by femtosecond time-resolved x-ray scattering in the gas phase using an x-ray free electron laser. In the femtosecond time domain, we find a very fast reaction that generates molecular fragments with one and two sulfur atoms. On picosecond and nanosecond timescales, a complex network of reactions unfolds that, ultimately, completes the sulfur dissociation from the parent molecule.

Identifiers

PMID39813348
PMCPMC11734709

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.