ArticleScience advances2025
Prior knowledge changes initial sensory processing in the human spinal cord.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Oxytocin Modulation of Spinal Circuits Drives Therapeutic Benefits of Massage.bioRxiv : the preprint server for biology · 2026Article
- Spatial distribution of spinal cord fMRI activity with electrocutaneous stimulation.medRxiv : the preprint server for health sciences · 2026Article
- Spatial distribution of spinal cord fMRI activity with electrocutaneous stimulation.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Electrical Spinal Imaging: A noninvasive, high-resolution approach that enables electrophysiological mapping of the human spinal cord.PLoS biology · 2025Article
- Altered processing of self-produced sensations in psychosis at cortical and spinal levels.Molecular psychiatry · 2025Article
- Spine-Prints: Transposing Brain Fingerprints to the Spinal Cord.bioRxiv : the preprint server for biology · 2025Article
- Evaluating cardiac noise correction approaches for non-invasive electrophysiology of the human spinal cord.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Spine-prints: Transposing brain fingerprints to the spinal cord.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prior knowledge changes how the brain processes sensory input. Whether knowledge influences initial sensory processing upstream of the brain, in the spinal cord, is unknown. Studying electric potentials recorded invasively and noninvasively from the human spinal cord at millisecond resolution, we find that the cord generates electric potentials at 600 hertz that are modulated by prior knowledge about the time of sensory input, as early as 13 to 16 milliseconds after stimulation. Our results reveal that already in the spinal cord, sensory processing is under top-down, cognitive control, and that 600-hertz signals, which have been identified as a macroscopic marker of population spiking in other regions of the nervous system, play a role in early, context-dependent sensory processing. The possibility to examine these signals noninvasively in humans opens up avenues for research into the physiology of the spinal cord and its interaction with the brain.
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