Evidence map›Paper›PMID 39813044›Full record

ArticleACS chemical biology2025

Amide Internucleoside Linkages Suppress the MicroRNA-like Off-Target Activity of Short Interfering RNA.

Chandan Pal, Michael Richter, Jayamini Harasgama, Eriks Rozners

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chandan PalDepartment of Chemistry, Binghamton University, the State University of New York, Binghamton, New York 13902, United States.
Michael RichterDepartment of Chemistry, Binghamton University, the State University of New York, Binghamton, New York 13902, United States.
Jayamini HarasgamaDepartment of Chemistry, Binghamton University, the State University of New York, Binghamton, New York 13902, United States.
Eriks RoznersDepartment of Chemistry, Binghamton University, the State University of New York, Binghamton, New York 13902, United States.ORCID 0000-0001-7649-0040

Funding

Chemical Approaches to Control the Function of Regulatory RNAsR35GM130207 · NIGMS · STATE UNIVERSITY OF NY,BINGHAMTON · PI ERIKS ROZNERS · 2019 to 2026
$3.7M
NIGMS NIH HHS R35 GM130207
6 · The paper itself

Abstract

RNA interference (RNAi) has rapidly matured as a novel therapeutic approach. In this field, chemical modifications have been critical to the clinical success of short interfering RNAs (siRNAs). Notwithstanding the significant advances, achieving robust durability and gene silencing in extrahepatic tissues, as well as reducing off-target effects of siRNA, are areas where chemical modifications can still improve siRNA performance. The present study developed the challenging synthesis of amide-linked guanosine dimers (G

Indexed as

AmidesMicroRNAsRNA, Small InterferingClass I Phosphatidylinositol 3-KinasesGuanosineHeLa CellsHumansNucleosidesRNA InterferenceYY1 Transcription FactorAmidesClass I Phosphatidylinositol 3-KinasesGuanosineMicroRNAsNucleosidesPIK3CB protein, humanRNA, Small InterferingYY1 Transcription Factor

Identifiers

PMID39813044
PMCPMC12522049

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.