Evidence map›Paper›PMID 39812990›Full record

ArticleSpine deformity2025

Outcomes and complications of vertebral body tethering by patient gender.

Julia Todderud, Todd Milbrandt, Alice Baroncini, Maty Petcharaporn, Michelle Marks, Daniel Hoernschemeyer, Peter Newton, Stefan Parent, Ahmet Alanay, Firoz Miyanji and 8 more

Abstract read
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In one paragraph

Article in Spine deformity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Julia TodderudDepartment of Orthopedic Surgery, Mayo Clinic, 200 First Street S.W, Rochester, MN, 55906, USA.
Todd MilbrandtDepartment of Orthopedic Surgery, Mayo Clinic, 200 First Street S.W, Rochester, MN, 55906, USA.
Alice BaronciniIRCCS Ospedale Galeazzi - Sant'Ambrogio, Milan, Italy.
Maty PetcharapornSetting Scoliosis Straight Foundation, Harms Study Group, San Diego, CA, USA.
Michelle MarksSetting Scoliosis Straight Foundation, Harms Study Group, San Diego, CA, USA.
Daniel HoernschemeyerSetting Scoliosis Straight Foundation, Harms Study Group, San Diego, CA, USA.
Peter NewtonSetting Scoliosis Straight Foundation, Harms Study Group, San Diego, CA, USA.
Stefan ParentSetting Scoliosis Straight Foundation, Harms Study Group, San Diego, CA, USA.
Ahmet AlanaySetting Scoliosis Straight Foundation, Harms Study Group, San Diego, CA, USA.
Firoz MiyanjiSetting Scoliosis Straight Foundation, Harms Study Group, San Diego, CA, USA.
Baron LonnerSetting Scoliosis Straight Foundation, Harms Study Group, San Diego, CA, USA.
Kevin NealSetting Scoliosis Straight Foundation, Harms Study Group, San Diego, CA, USA.
Burt YaszaySetting Scoliosis Straight Foundation, Harms Study Group, San Diego, CA, USA.
Laurel BlakemoreSetting Scoliosis Straight Foundation, Harms Study Group, San Diego, CA, USA.
Suken ShahSetting Scoliosis Straight Foundation, Harms Study Group, San Diego, CA, USA.
Lawrence HaberSetting Scoliosis Straight Foundation, Harms Study Group, San Diego, CA, USA.
Amer SamdaniSetting Scoliosis Straight Foundation, Harms Study Group, San Diego, CA, USA.
A Noelle LarsonDepartment of Orthopedic Surgery, Mayo Clinic, 200 First Street S.W, Rochester, MN, 55906, USA. larson.noelle@mayo.edu.ORCID http://orcid.org/0000-0001-6542-6975

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNon-fusion surgical options for pediatric scoliosis management such as vertebral body tethering (VBT) offer an alternative to spinal fusion. With this study, we aim to evaluate the postoperative outcomes in boys versus girls who have undergone VBT. Our hypothesis is that girls and boys will have similar outcomes by 2-year follow-up.

methodsThis study employed a review of retrospective data for patients who underwent VBT at 10 sites between 2011 and 2020. Patients were stratified based on gender. All patients had preoperative and 2-year follow-up and were evaluated for curve correction, complications, surgery metrics, and patient reported outcomes.

results328 patients were included in this study: 277 girls and 51 boys. Mean age at surgery was 12.2 years for girls and 13.4 years for boys. Mean preoperative curve magnitude and curve flexibility was similar between both groups. Compared to girls, boys were older, heavier and taller at the time of surgery; BMI was not different between the groups. Skeletal maturity was not different preoperatively or at 2 years. There were no significant differences for mean operative time, mean estimated blood loss, or levels instrumented. Postoperative stay was longer in the girls averaging 4.5 days compared to 3.9 days for the boys (p = 0.026). There were no statistically significant differences between boys and girls for the curve magnitude at final follow-up (28° vs 25° thoracic, 21° both groups lumbar) or percent correction (45% vs 38% thoracic, 38% vs 31% lumbar) at 2-year follow-up. Overall, 98 girls (35%) experienced medical or surgical complications compared to 18 boys (39%) (p = 0.599). Boys experienced higher rates of tether breakage at latest follow-up (33% vs. 17%, p = 0.008) and more loss of correction > 10° (10% vs. 3%, p = 0.03). Rates of reoperation were 15.9% in the girls and 15.7% in the boys (p = 0.972).

conclusionOur study found that boys on average had higher body weight than girls and also higher rates of tether cord breakage and loss of correction. Despite these differences, curve correction, modulation, and reoperation rates were similar in both groups. Further work is needed to determine the relative impact of patient gender and weight on incidence of tether breakage.

Indexed as

Postoperative ComplicationsScoliosisVertebral BodyAdolescentChildFemaleFollow-Up StudiesHumansMaleRetrospective StudiesSex FactorsSpinal FusionTreatment OutcomeAdolescent idiopathic scoliosisGenderSexTetherVertebral body tethering

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.