Evidence map›Paper›PMID 39812961›Full record

Observational studyQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2025

Impact of surgery versus follow-up on psychological distress in patients with indeterminate pulmonary nodules: A prospective observational study.

Junhan Wu, Weitao Zhuang, Rixin Chen, Haijie Xu, Zijie Li, Zihua Lan, Xin Xia, Zhe He, Shaopeng Li, Cheng Deng and 4 more

Registry-linked trialAbstract readObservational StudyComparative Study
PubMed Publisher
In one paragraph

Observational study in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04857333 (Dynamic Evolution of Pulmonary Nodules and Influence Factors of Its Clinical Decision-making), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04857333 unknown statusnot on this map

Dynamic Evolution of Pulmonary Nodules and Influence Factors of Its Clinical Decision-making: A Prospective Cohort Study

Typeobservational_patient_registrySponsorGuiBin QiaoRan2021 to 2025Enrolled1,800ConditionsPulmonary Nodule, Solitary, Pulmonary Nodule, MultipleArmsCT scan, Antibiotics, Surgical Resection
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Junhan Wu *Shantou University Medical College, Shantou, 515041, China.ORCID http://orcid.org/0000-0002-3726-5948
Weitao Zhuang *Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.ORCID http://orcid.org/0000-0002-8679-4109
Rixin Chen *Department of Thoracic Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510000, China.
Haijie XuShantou University Medical College, Shantou, 515041, China.
Zijie LiShantou University Medical College, Shantou, 515041, China.
Zihua LanShantou University Medical College, Shantou, 515041, China.
Xin XiaDepartment of Thoracic Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510000, China.
Zhe HeThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510000, China.
Shaopeng LiDepartment of Thoracic Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510000, China.
Cheng DengDepartment of Thoracic Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510000, China.
Wei XuSchool of Public Health, Chongqing Medical University, Chongqing, 400016, China.
Qiuling ShiSchool of Public Health, Chongqing Medical University, Chongqing, 400016, China.ORCID http://orcid.org/0000-0003-0660-3809
Yong TangDepartment of Thoracic Surgery, Shenzhen Nanshan People's Hospital, Shenzhen, 518052, China. ywz1112@sina.com.
Guibin QiaoShantou University Medical College, Shantou, 515041, China. guibinqiao@126.com.ORCID http://orcid.org/0000-0001-9200-9317

Funding

the National Key R&D Program of China 2022YFE0133100
6 · The paper itself

Abstract

purposeTo investigate whether surgery is more effective than follow-up in reducing psychological distress for patients with observable indeterminate pulmonary nodules (IPNs) and to assess if psychological distress can serve as a potential surgical indication for IPNs.

methodsThis prospective observational study included 341 patients with abnormal psychometric results, as measured by the Hospital Anxiety and Depression Scale (HADS). Of these, 262 patients opted for follow-up and 79 chose surgery. Initial psychological assessments (HADS1) were conducted at enrollment following nodule detection, with a second assessment (HADS2) one year later. A comparative analysis of dynamic psychological changes (ΔHADS: HADS2-HADS1) between the follow-up and surgical groups was performed.

resultsBoth groups showed reductions in HADS-A [- 3 (IQR, - 7 to - 1) for follow-up and - 3 (IQR, - 6 to - 1) for surgery] and HADS-D scores [- 2 (IQR, - 4 to 0) for follow-up and - 3 (IQR, - 7 to 0) for surgery]. Univariate analysis revealed that the surgical group had a significantly greater reduction in HADS-D scores compared to the follow-up group (Z = - 2.08, P = 0.037), but there were no significant differences in the changes in HADS-A scores between the groups (Z = - 1.04, P = 0.300). However, in multivariable analysis, surgery did not significantly improve the alleviation of depressive symptoms compared to follow-up (β = - 0.72, 95% CI: - 1.57 to 0.14, P = 0.101). Within the surgical group, female patients reported less relief from anxiety than male patients (Z = - 2.32, P = 0.021), and symptomatic patients experienced less relief from both anxiety (Z = - 2.14, P = 0.032) and depression (Z = - 3.01, P = 0.003).

conclusionsSurgery does not provide additional psychological benefits over follow-up. This study does not support using psychological distress as a criterion for surgical intervention in IPNs from a psychological perspective. Trial registry ClinicalTrials.gov (NCT04857333).

Indexed as

Lung NeoplasmsMultiple Pulmonary NodulesPsychological DistressSolitary Pulmonary NoduleStress, PsychologicalAdultAgedAnxietyDepressionFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesPsychometricsFollow-upPsychological distressPulmonary nodule (PN)Surgery

Identifiers

PMID39812961

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.