Evidence map›Paper›PMID 39812953›Full record

ReviewCurrent HIV/AIDS reports2025

HIV Prevention in Syringe Service Programs Since the Start of COVID-19: Where Do We Go From Here?

Mary A Hatch, Melissa Ertl, David Closs, Susana Keeshin, Judith Feinberg, Kai Orozco, Susan Tross

Abstract readReview
In one paragraph

Review in Current HIV/AIDS reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mary A HatchAddictions, Drug & Alcohol Institute, Department of Psychiatry & Behavioral Sciences, University of Washington, 1959 NE Pacific St., Box 356560, Seattle, WA, 98195-6560, USA. hatchm@uw.edu.ORCID http://orcid.org/0000-0002-1086-9493
Melissa ErtlDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-1022-1777
David ClossFriends for All, Memphis, TN, USA.
Susana KeeshinDepartment of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0001-8317-5508
Judith FeinbergDepartments of Behavioral Medicine and Psychiatry & Medicine/Infectious Disease, West Virginia University School of Medicine, Morgantown, WV, USA.ORCID http://orcid.org/0000-0003-4206-7214
Kai OrozcoAddictions, Drug & Alcohol Institute, Department of Psychiatry & Behavioral Sciences, University of Washington, 1959 NE Pacific St., Box 356560, Seattle, WA, 98195-6560, USA.
Susan TrossColumbia University Irving Medical School, New York, NY, USA.

Funding

Project-003UG1DA013035 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Aimee N Campbell, Jennifer McNeely · 2015 to 2026
$130.3M
Clinical Trials Network: Pacific Northwest Node (CTN-0082, -0131, -0139 and dissemination library)UG1DA013714 · NIDA · UNIVERSITY OF WASHINGTON · PI Mary Akiko Hatch, John M. Roll · 2015 to 2026
$19.8M
Project-008UG1DA049436 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jane M. Liebschutz, Erin L Winstanley · 2019 to 2026
$10.5M
Integrating Addiction and Infectious Diseases Services into Primary Care in Rural SettingsR01DA054703 · NIDA · YALE UNIVERSITY · PI FREDERICK LEWIS ALTICE, JUDITH FEINBERG · 2021 to 2026
$5.7M
Off-label Use of Rapid Response Fentanyl Test Strips as an Opioid Overdose Prevention StrategyR01DA047334 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI FEINBERG, JUDITH, ZIBBELL, JON ERIC · 2020 to 2022
$1.9M
Enhanced Interdisciplinary Research Training InstituteR25DA050687 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VALDEZ, AVELARDO · 2020 to 2024
$1.3M
Gilead FOCUS partnership 2344National Institute on Drug Abuse (NIDA) National Drug Abuse Treatment Clinical Trials Network UG1DA013035National Institute on Drug Abuse (NIDA) National Drug Abuse Treatment Clinical Trials Network UG1DA013714National Institute on Drug Abuse (NIDA) National Drug Abuse Treatment Clinical Trials Network UG1DA049436NIDA and NIAAA R25-DA050687-01A1NIDA NIH HHS R01 DA047334NIDA NIH HHS R01 DA054703NIDA NIH HHS R01DA054703NIDA NIH HHS R25 DA050687NIDA NIH HHS UG1 DA013035NIDA NIH HHS UG1 DA013714NIDA NIH HHS UG1 DA049436
6 · The paper itself

Abstract

purposeThis narrative review addresses post-2020, specific, complex challenges for use of and adherence to pre-exposure prophylaxis (PrEP) for HIV prevention among out-of-treatment people who use drugs (PWUD) at syringe services programs (SSPs). RECENT

findingsThe COVID-19 pandemic and its associated changes to the provision of healthcare have significantly impacted HIV prevention, especially for PWUD. Through a synthesis of literature and clinical experience, we (1) characterize the operational changes imposed by the pandemic on SSPs that shaped the current HIV prevention landscape; (2) describe three levels of current challenges for PWUD, including consumer attitudes, non-medical and medical provider attitudes, and structural and scalability barriers; (3) characterize current models for PrEP in SSPs; and (4) offer practical recommendations for HIV prevention in harm reduction programs. PrEP is a highly effective prevention tool if taken as prescribed. It has been enthusiastically promoted by members of the research, public health and provider communities. Despite its efficacy, PWUD struggle to engage with the PrEP care continuum. We highlight opportunities to advance HIV prevention for PWUD by enhancing tailored, whole-person approaches that may set aside PrEP in favor of other risk reduction routes. For most PWUD who receive services at SSPs, PrEP is a single tool and not realistic until other social and structural determinants of health are addressed.

Indexed as

COVID-19HIV InfectionsNeedle-Exchange ProgramsPre-Exposure ProphylaxisSubstance Abuse, IntravenousAnti-HIV AgentsHarm ReductionHumansSARS-CoV-2Anti-HIV AgentsHarm reductionHIV pre-exposure prophylaxis (PrEP)HIV preventionPeople who inject drugsPeople who use drugsSyringe services programs

Identifiers

PMID39812953
PMCPMC12640190

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.