Evidence map›Paper›PMID 39812814›Full record

ArticleInternational urogynecology journal2025

Cardiometabolic Index and Stress Urinary Incontinence in US Women: The Mediating Role of the Triglyceride Glucose Index.

Qian Yang, Yue Cao

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Article in International urogynecology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Qian YangThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Yue CaoThe Second School of Clinical Medicine, Southern Medical University, Guangzhou, China. caoyuegege@yeah.net.ORCID 0009-0003-1950-5682

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStress urinary incontinence (SUI) is a prevalent condition among women, significantly impairing their quality of life. Emerging evidence suggests that metabolic dysfunction may play a role in the development of SUI, although the underlying mechanisms remain unclear. This study aims to examine the association between the cardiometabolic index (CMI), a novel marker of metabolic health, and the risk of SUI in women.

methodsCross-sectional data from the 2001-2020 NHANES were analyzed. Weighted multivariable logistic regression models assessed the relationship between CMI and SUI risk, while restricted cubic spline (RCS) models examined potential nonlinear associations. Subgroup analyses and interaction tests were performed to explore how specific characteristics influenced the CMI-SUI relationship. Mediation analysis was performed to evaluate whether the triglyceride glucose (TyG) index mediated the CMI-SUI association. Sensitivity analyses using propensity score matching (PSM) ensured the robustness of the findings.

resultsHigher CMI was significantly associated with increased SUI risk in women (P < 0.001). RCS analysis revealed a nonlinear relationship, with a threshold at 1.64. Below this point, reducing CMI was significantly associated with a lower risk of SUI (overall P < 0.001, linear P < 0.001). Subgroup and interaction analyses showed stronger associations among women under 65 years, those with higher education, those without a history of hypertension or diabetes, and women taking oral contraceptives (P for interaction < 0.05). Mediation analysis showed that the TyG index completely mediated the relationship between CMI and SUI, accounting for 97.67% of the total effect. Sensitivity analyses using PSM confirmed the robustness of these results.

conclusionThis study highlights that a higher CMI is associated with an increased risk of SUI in women, and this relationship may be largely mediated by the TyG index.

Indexed as

Blood GlucoseCardiometabolic Risk FactorsTriglyceridesUrinary Incontinence, StressAdultAgedCross-Sectional StudiesFemaleHumansMiddle AgedNutrition SurveysUnited StatesBlood GlucoseTriglyceridesCardiometabolic indexCross-sectional analysisNHANESStress urinary incontinenceTriglyceride glucose index

Identifiers

PMID39812814

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.