Evidence map›Paper›PMID 39812811›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2025

The role of mTOR activation in steroid-resistant asthma: insights from particulate matter-induced mouse model and patient studies.

Heung-Woo Park, Suh-Young Lee, Hyun Seung Lee

Abstract read
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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Heung-Woo ParkDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0001-7276-8519
Suh-Young LeeDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-6970-3228
Hyun Seung LeeInstitute of Allergy and Clinical Immunology, Biomedical Research Institute, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea. gentlehood79@hanmail.net.ORCID http://orcid.org/0000-0002-4599-8527

Funding

the National Research Foundation of Korea(NRF) grant funded by the Korea government (MSIT) NRF-2022R1F1A1072595
6 · The paper itself

Abstract

Particulate matter (PM) exposure has been proposed as one of the causes of steroid resistance. However, studies investigating this using patient samples or animals are still lacking. Therefore, in this study, we aimed to investigate the changes in cytokines and mTOR (mammalian target of rapamycin) activation in patients with steroid resistant asthma and the role of mTOR in a mouse model of steroid resistant asthma induced by PM. In mouse experiment, on administering PM10 and allergen (Dp) through the intranasal route for 3 weeks, airway hyperresponsiveness (AHR), eosinophils, and airway inflammation were increased. However, administering rapamycin (mTOR inhibitor) together with PM and Dp led to significant decrease in all of the abovementioned features; additionally, the population of IL-13 + or IL-17 + cells in CD62

Indexed as

AsthmaParticulate MatterTOR Serine-Threonine KinasesAdultAllergensAnimalsCytokinesDisease Models, AnimalDrug ResistanceFemaleHumansMaleMiceMice, Inbred BALB CMiddle AgedSirolimusAllergensCytokinesMTOR protein, humanParticulate MatterSirolimusTOR Serine-Threonine KinasesAsthmaMechanistic target of RapamycinParticulate matterSteroids

Identifiers

PMID39812811

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.