Trial reportNaunyn-Schmiedeberg's archives of pharmacology2025
Ranolazine effectively improves clinical symptoms in patients with slow flow coronary arteries: a randomized, double-blind, placebo-controlled clinical trial.
Trial report in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Topical lidocaine effectively mitigates radial pain, spasm, and sympathetic response following trans-radial coronary angiography: A randomized, double-blind, placebo-controlled clinical trial.Naunyn-Schmiedeberg's archives of pharmacology · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The coronary slow flow phenomenon (CSF) causes persistent chest pains that can affect patients' quality of life. We aimed to examine the ranolazine impacts on clinical symptoms in CSF patients. The present randomized, double-blind, placebo-controlled trial consisted of 44 patients with CSF. For two months, patients were randomized to receive ranolazine (500 mg/twice daily) or placebo plus optimal medications. EuroQol-visual analogic scale (VAS) and Seattle Angina Questionnaire (SAQ) were performed at baseline and after one and two months of treatment. At the beginning and after one month of treatment, no remarkable difference was assumed in the mean of EuroQol-VAS and all five SAQ parameters between the ranolazine and placebo groups. Additionally, the median of EuroQol-VAS (P < 0.001) and all five SAQ parameters, including physical limitation (P < 0.001), stability of angina (P < 0.001), frequency of angina (P < 0.001), treatment satisfaction (P = 0.003 and P < 0.001), and understanding of the disease (P < 0.001), has significantly propagated after two months of treatment in both ranolazine and placebo groups. Interestingly, following two months of treatment, the mean of EuroQol-VAS (P = 0.013), physical limitation (P = 0.041), stability of angina (P = 0.016), frequency of angina (P = 0.042), and treatment satisfaction (P = 0.037), in the ranolazine group has notably elevated comparatively to the placebo group. Our findings showed that ranolazine ameliorates clinical symptoms in CSF patients after two months of treatment. Therefore, ranolazine may be an appropriate candidate in CSF patients.
Indexed as
Identifiers
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Registered trials
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