Evidence map›Paper›PMID 39812708›Full record

ArticleThe Journal of cell biology2025

Classical cell cycle kinase limits tubulin polyglutamylation and cilium stability.

Xiaoliang Liu, Xuecai Ge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Xiaoliang LiuDepartment of Molecular and Cell Biology, University of California, Merced, Merced, CA, USA.ORCID 0009-0008-9296-9025
Xuecai GeDepartment of Molecular and Cell Biology, University of California, Merced, Merced, CA, USA.ORCID 0000-0002-5896-0800

Funding

Regulation of the Hedgehog Pathway by new cilium proteins in Development and DiseaseR01GM143276 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI GE, XUECAI · 2022 to 2025
$1.5M
Target PDE4D to inhibit the Hedgehog pathwayR15CA235749 · NCI · UNIVERSITY OF CALIFORNIA, MERCED · PI GE, XUECAI · 2019 to 2022
$795k
Mechanistic study of Hedgehog signaling in the ciliumR21CA274595 · NCI · UNIVERSITY OF CALIFORNIA, MERCED · PI GE, XUECAI · 2022 to 2022
$385k
National Science Foundation IOS-2143711NCI NIH HHS CA235749NCI NIH HHS R15 CA235749NCI NIH HHS R21 CA274595NIGMS NIH HHS GM143276NIGMS NIH HHS R01 GM143276NIH HHS
6 · The paper itself

Abstract

Tubulin polyglutamylation is essential for maintaining cilium stability and function, and defective tubulin polyglutamylation is associated with ciliopathies. However, the regulatory mechanism underlying proper axonemal polyglutamylation remains unclear. He et al. (https://doi.org/10.1083/jcb.202405170) discovered that Cdk7/Cdk6/FIP5 phosphorylation cascade controls the ciliary import of tubulin glutamylases, thereby modulating axoneme polyglutamylation and ciliary signaling.

Indexed as

CiliaPolyglutamic AcidTubulinAnimalsAxonemeCell CycleHumansPhosphorylationSignal TransductionPolyglutamic AcidTubulin

Identifiers

PMID39812708
PMCPMC11734621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.