Evidence map›Paper›PMID 39812699›Full record

ArticleThe Journal of membrane biology2025

Pharmacodynamic characterization and evaluation of oxidative stress effects of digitoxigenin derivatives on HeLa cells.

Jessica M M Valadares, Pedro Azalim-Neto, Xiaofan Liu, Nathallia Cavalcanti Carrozza, George A O'Doherty, Luis Eduardo M Quintas, Leandro A Barbosa

Abstract read
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In one paragraph

Article in The Journal of membrane biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jessica M M Valadares *Laboratório de Bioquímica Celular, Universidade Federal de São João del-Rei (UFSJ), Divinópolis, Brazil.
Pedro Azalim-Neto *Laboratório de Farmacologia Bioquímica e Molecular, Instituto de Ciências Biomédicas, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil.
Xiaofan LiuDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115, USA.
Nathallia Cavalcanti CarrozzaLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei (UFSJ), Divinópolis, Brazil.
George A O'DohertyDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115, USA.
Luis Eduardo M QuintasLaboratório de Farmacologia Bioquímica e Molecular, Instituto de Ciências Biomédicas, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, 21941-902, Brazil. lquintas@icb.ufrj.br.ORCID 0000-0002-0767-1240
Leandro A BarbosaLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei (UFSJ), Divinópolis, Brazil.

Funding

Fusidic acid derivatization to enhance entry into Gram-negative pathogensR21AI146485 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KIRBY, JAMES E, O'DOHERTY, GEORGE A · 2019 to 2020
$475k
Conselho Nacional de Desenvolvimento Científico e Tecnológico 401914/2016-0Conselho Nacional de Desenvolvimento Científico e Tecnológico 409436/2016-0Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro 210.436/2024Fundação de Amparo à Pesquisa do Estado de Minas Gerais 00290-16NIAID NIH HHS R21 AI146485NIH HHS AI146485
6 · The paper itself

Abstract

Cancer is a leading cause of death worldwide and its treatment is hampered by the lack of specificity and side effects of current drugs. Cardiotonic steroids (CTS) interact with Na

Indexed as

Antineoplastic AgentsDigitoxigeninOxidative StressGlutathioneHeLa CellsHumansHydrogen PeroxideLipid PeroxidationSodium-Potassium-Exchanging ATPaseSuperoxide DismutaseAntineoplastic AgentsDigitoxigeninGlutathioneHydrogen PeroxideSodium-Potassium-Exchanging ATPaseSuperoxide DismutaseAntineoplastic agentsCardiac glycosidesMolecular mechanisms of pharmacological actionOxidative damageP-Type ATPases

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.