Evidence map›Paper›PMID 39812607›Full record

ArticleEpilepsia2025

Lateralizing value of interictal epileptiform discharges and other parameters in hypothalamic hamartoma.

Friederike Niedermoser, Sarah M Metzger, Kathrin Wagner, Peter C Reinacher, Jan Schönberger, Julia Jacobs-LeVan, Andreas Schulze-Bonhage, Kerstin Alexandra Klotz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Friederike NiedermoserDepartment of Neuropediatrics and Muscular Disorders, Medical Center, Faculty of Medicine University of Freiburg, University of Freiburg, Freiburg im Breisgau, Germany.
Sarah M MetzgerDepartment of Neuropediatrics and Muscular Disorders, Medical Center, Faculty of Medicine University of Freiburg, University of Freiburg, Freiburg im Breisgau, Germany.ORCID https://orcid.org/0000-0001-7730-9733
Kathrin WagnerEpilepsy Center, Medical Center, Faculty of Medicine University of Freiburg, University of Freiburg, Freiburg im Breisgau, Germany.ORCID https://orcid.org/0000-0003-2232-1684
Peter C ReinacherDepartment of Stereotactic and Functional Neurosurgery, Medical Center, Faculty of Medicine University of Freiburg, University of Freiburg, Freiburg im Breisgau, Germany.ORCID https://orcid.org/0000-0003-1691-546X
Jan SchönbergerDepartment of Neuropediatrics and Muscular Disorders, Medical Center, Faculty of Medicine University of Freiburg, University of Freiburg, Freiburg im Breisgau, Germany.ORCID https://orcid.org/0000-0002-5448-7825
Julia Jacobs-LeVanDepartment of Neuropediatrics and Muscular Disorders, Medical Center, Faculty of Medicine University of Freiburg, University of Freiburg, Freiburg im Breisgau, Germany.ORCID https://orcid.org/0000-0003-1164-4699
Andreas Schulze-BonhageEpilepsy Center, Medical Center, Faculty of Medicine University of Freiburg, University of Freiburg, Freiburg im Breisgau, Germany.ORCID https://orcid.org/0000-0003-2382-0506
Kerstin Alexandra KlotzDepartment of Neuropediatrics and Muscular Disorders, Medical Center, Faculty of Medicine University of Freiburg, University of Freiburg, Freiburg im Breisgau, Germany.ORCID https://orcid.org/0000-0002-1601-5384

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHypothalamic hamartomas (HHs) are associated with pharmacoresistant epilepsy. Stereotactic radiofrequency thermocoagulation (SRT) shows promise as a disconnecting intervention. Although magnetic resonance imaging (MRI) is typically used to determine the attachment and intervention side, it presents challenges in cases of bilaterally attached HH, where the epileptogenic side is unclear. The lateralizing potential of electroclinical parameters in such cases remains uncertain. This retrospective study evaluates the lateralization value of specific parameters, particularly in patients with unilateral HH, to improve future diagnostics and treatment approaches for bilateral HH.

methodsFour lateralizing parameters-semiology, ictal electroencephalography (EEG), and interictal epileptiform discharges during awake (IEDs

resultsWe included 25 patients (2-55 years of age) with mainly unilateral (n = 22) HHs who underwent SRT and presurgical evaluation. All parameters correlated with HH attachment side (semiology R = -.62, p = .005; ictal EEG R = .51, p = .047; IED SIGNIFICANCE: IEDs

Indexed as

Drug Resistant EpilepsyFunctional LateralityHamartomaHypothalamic DiseasesAdolescentAdultChildChild, PreschoolElectroencephalographyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRetrospective StudiesYoung Adultbilateralbiomarkerinterictal epileptiform dischargessemiologystereotactic radiofrequency thermocoagulation

Identifiers

PMID39812607
PMCPMC11908668

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.