Evidence map›Paper›PMID 39812604›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Ablation of satellite cell-specific clock gene, Bmal1, alters force production, muscle damage, and repair following contractile-induced injury.

Ryan E Kahn, Pei Zhu, Ishan Roy, Clara Peek, John A Hawley, Sudarshan Dayanidhi

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Ablation of satellite cell-specific clock gene, Bmal1, alters force production, muscle damage, and repair following contractile-induced injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ryan E KahnExercise and Nutrition Research Program, The Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.ORCID https://orcid.org/0009-0006-9592-9390
Pei ZhuDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0001-9257-5394
Ishan RoyShirley Ryan AbilityLab, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-9109-0421
Clara PeekDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-0873-0879
John A HawleyExercise and Nutrition Research Program, The Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.ORCID https://orcid.org/0000-0002-0886-9881
Sudarshan DayanidhiShirley Ryan AbilityLab, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0001-7534-0497

Funding

Role of muscle stem cells in sarcomere addition and contracturesR03HD094602 · NICHD · REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB · PI DAYANIDHI, SUDARSHAN · 2018 to 2019
$319k
HHS | National Institutes of Health (NIH) HD094602NICHD NIH HHS R03 HD094602Novo Nordisk Foundation Center for Basic Metabolic Research (NovoNordisk Foundation Center for Basic Metabolic Research) NNF14OC0011493
6 · The paper itself

Abstract

Following injury, skeletal muscle undergoes repair via satellite cell (SC)-mediated myogenic progression. In SCs, the circadian molecular clock gene, Bmal1, is necessary for appropriate myogenic progression and repair with evidence that muscle molecular clocks can also affect force production. Utilizing a mouse model allowing for inducible depletion of Bmal1 within SCs, we determined contractile function, SC myogenic progression and muscle damage and repair following eccentric contractile-induced injury. At baseline, SC-Bmal1

Indexed as

ARNTL Transcription FactorsMuscle ContractionMuscle, SkeletalSatellite Cells, Skeletal MuscleAnimalsMaleMiceMice, Inbred C57BLMice, KnockoutARNTL Transcription FactorsBmal1 protein, mousecontractile injuryforce productionmolecular clocksmuscle repairmuscle stem cellsmyogenic progression

Identifiers

PMID39812604
PMCPMC11734708

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.