Evidence map›Paper›PMID 39812584›Full record

ArticleRadiology. Artificial intelligence2025

NNFit: A Self-Supervised Deep Learning Method for Accelerated Quantification of High-Resolution Short-Echo-Time MR Spectroscopy Datasets.

Alexander S Giuffrida, Sulaiman Sheriff, Vicki Huang, Brent D Weinberg, Lee A D Cooper, Yuan Liu, Brian J Soher, Michael Treadway, Andrew A Maudsley, Hyunsuk Shim

Abstract read
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In one paragraph

Article in Radiology. Artificial intelligence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Alexander S GiuffridaFrom the Department of Radiation Oncology (A.S.G., V.H., H.S.) and Department of Radiology and Imaging Sciences (B.D.W.), Emory University School of Medicine, 1701 Uppergate Dr, C5008 Winship Cancer Institute, Atlanta, GA 30322; Department of Radiology, University of Miami School of Medicine, Miami, Fla (S.S., A.A.M.); Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.A.D.C.); Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Ga (Y.L.); Department of Psychology, Emory University, Atlanta, Ga (M.T.); and Department of Radiology, Duke University Medical Center, Durham, NC (B.J.S.).ORCID 0000-0001-6512-0992
Sulaiman SheriffFrom the Department of Radiation Oncology (A.S.G., V.H., H.S.) and Department of Radiology and Imaging Sciences (B.D.W.), Emory University School of Medicine, 1701 Uppergate Dr, C5008 Winship Cancer Institute, Atlanta, GA 30322; Department of Radiology, University of Miami School of Medicine, Miami, Fla (S.S., A.A.M.); Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.A.D.C.); Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Ga (Y.L.); Department of Psychology, Emory University, Atlanta, Ga (M.T.); and Department of Radiology, Duke University Medical Center, Durham, NC (B.J.S.).
Vicki HuangFrom the Department of Radiation Oncology (A.S.G., V.H., H.S.) and Department of Radiology and Imaging Sciences (B.D.W.), Emory University School of Medicine, 1701 Uppergate Dr, C5008 Winship Cancer Institute, Atlanta, GA 30322; Department of Radiology, University of Miami School of Medicine, Miami, Fla (S.S., A.A.M.); Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.A.D.C.); Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Ga (Y.L.); Department of Psychology, Emory University, Atlanta, Ga (M.T.); and Department of Radiology, Duke University Medical Center, Durham, NC (B.J.S.).ORCID 0000-0003-3029-4700
Brent D WeinbergFrom the Department of Radiation Oncology (A.S.G., V.H., H.S.) and Department of Radiology and Imaging Sciences (B.D.W.), Emory University School of Medicine, 1701 Uppergate Dr, C5008 Winship Cancer Institute, Atlanta, GA 30322; Department of Radiology, University of Miami School of Medicine, Miami, Fla (S.S., A.A.M.); Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.A.D.C.); Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Ga (Y.L.); Department of Psychology, Emory University, Atlanta, Ga (M.T.); and Department of Radiology, Duke University Medical Center, Durham, NC (B.J.S.).ORCID 0000-0002-7992-1747
Lee A D CooperFrom the Department of Radiation Oncology (A.S.G., V.H., H.S.) and Department of Radiology and Imaging Sciences (B.D.W.), Emory University School of Medicine, 1701 Uppergate Dr, C5008 Winship Cancer Institute, Atlanta, GA 30322; Department of Radiology, University of Miami School of Medicine, Miami, Fla (S.S., A.A.M.); Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.A.D.C.); Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Ga (Y.L.); Department of Psychology, Emory University, Atlanta, Ga (M.T.); and Department of Radiology, Duke University Medical Center, Durham, NC (B.J.S.).
Yuan LiuFrom the Department of Radiation Oncology (A.S.G., V.H., H.S.) and Department of Radiology and Imaging Sciences (B.D.W.), Emory University School of Medicine, 1701 Uppergate Dr, C5008 Winship Cancer Institute, Atlanta, GA 30322; Department of Radiology, University of Miami School of Medicine, Miami, Fla (S.S., A.A.M.); Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.A.D.C.); Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Ga (Y.L.); Department of Psychology, Emory University, Atlanta, Ga (M.T.); and Department of Radiology, Duke University Medical Center, Durham, NC (B.J.S.).ORCID 0000-0001-8926-3058
Brian J SoherFrom the Department of Radiation Oncology (A.S.G., V.H., H.S.) and Department of Radiology and Imaging Sciences (B.D.W.), Emory University School of Medicine, 1701 Uppergate Dr, C5008 Winship Cancer Institute, Atlanta, GA 30322; Department of Radiology, University of Miami School of Medicine, Miami, Fla (S.S., A.A.M.); Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.A.D.C.); Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Ga (Y.L.); Department of Psychology, Emory University, Atlanta, Ga (M.T.); and Department of Radiology, Duke University Medical Center, Durham, NC (B.J.S.).
Michael TreadwayFrom the Department of Radiation Oncology (A.S.G., V.H., H.S.) and Department of Radiology and Imaging Sciences (B.D.W.), Emory University School of Medicine, 1701 Uppergate Dr, C5008 Winship Cancer Institute, Atlanta, GA 30322; Department of Radiology, University of Miami School of Medicine, Miami, Fla (S.S., A.A.M.); Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.A.D.C.); Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Ga (Y.L.); Department of Psychology, Emory University, Atlanta, Ga (M.T.); and Department of Radiology, Duke University Medical Center, Durham, NC (B.J.S.).ORCID 0000-0002-5913-114X
Andrew A MaudsleyFrom the Department of Radiation Oncology (A.S.G., V.H., H.S.) and Department of Radiology and Imaging Sciences (B.D.W.), Emory University School of Medicine, 1701 Uppergate Dr, C5008 Winship Cancer Institute, Atlanta, GA 30322; Department of Radiology, University of Miami School of Medicine, Miami, Fla (S.S., A.A.M.); Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.A.D.C.); Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Ga (Y.L.); Department of Psychology, Emory University, Atlanta, Ga (M.T.); and Department of Radiology, Duke University Medical Center, Durham, NC (B.J.S.).ORCID 0000-0001-7653-3063
Hyunsuk ShimFrom the Department of Radiation Oncology (A.S.G., V.H., H.S.) and Department of Radiology and Imaging Sciences (B.D.W.), Emory University School of Medicine, 1701 Uppergate Dr, C5008 Winship Cancer Institute, Atlanta, GA 30322; Department of Radiology, University of Miami School of Medicine, Miami, Fla (S.S., A.A.M.); Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Ill (L.A.D.C.); Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Ga (Y.L.); Department of Psychology, Emory University, Atlanta, Ga (M.T.); and Department of Radiology, Duke University Medical Center, Durham, NC (B.J.S.).ORCID 0000-0001-8313-2612

Funding

Glutamatergic adaptation to stress as a mechanism for anhedonia and treatment response with ketamineR01MH126083 · NIMH · EMORY UNIVERSITY · PI Michael Tilghman Treadway · 2022 to 2026
$3.9M
Improved whole-brain spectroscopic MRI for radiation therapy planningU01CA264039 · NCI · EMORY UNIVERSITY · PI Lee Cooper, Eric Albert Mellon · 2022 to 2026
$3.1M
NCI NIH HHS U01 CA264039NIMH NIH HHS R01 MH126083
6 · The paper itself

Abstract

Purpose To develop and evaluate the performance of NNFit, a self-supervised deep learning method for quantification of high-resolution short-echo-time (TE) echo-planar spectroscopic imaging (EPSI) datasets, with the goal of addressing the computational bottleneck of conventional spectral quantification methods in the clinical workflow. Materials and Methods This retrospective study included 89 short-TE whole-brain EPSI/generalized autocalibrating partial parallel acquisition scans from clinical trials for glioblastoma (trial 1, May 2014-October 2018) and major depressive disorder (trial 2, 2022-2023). The training dataset included 685 000 spectra from 20 participants (60 scans) in trial 1. The testing dataset included 115 000 spectra from five participants (13 scans) in trial 1 and 145 000 spectra from seven participants (16 scans) in trial 2. A comparative analysis was performed between NNFit and a widely used parametric-modeling spectral quantitation method (FITT). Metabolite maps generated by each method were compared using the structural similarity index measure (SSIM) and linear correlation coefficient (

Indexed as

Brain NeoplasmsDeep LearningEcho-Planar ImagingBrainFemaleGlioblastomaHumansMagnetic Resonance SpectroscopyMajor Depressive DisorderMaleRetrospective StudiesBrain/Brain StemMR SpectroscopyNeural Networks

Identifiers

PMID39812584
PMCPMC11950874

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.