Evidence map›Paper›PMID 39812388›Full record

ArticleJournal of studies on alcohol and drugs2025

Body Mass Index Is Inversely Associated With Level of Response to Alcohol: Role of Total Body Water.

Rhianna R Vergeer, Bethany L Stangl, Matthew E Sloan, Christina C Kennard, Shyamala K Venkatesh, Paule V Joseph, Melanie L Schwandt, Marta Yanina Pepino, Nancy Diazgranados, Vijay A Ramchandani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of studies on alcohol and drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rhianna R VergeerHuman Psychopharmacology Laboratory, Division of Intramural Clinical and Biological Research (DICBR), National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland.
Bethany L StanglHuman Psychopharmacology Laboratory, Division of Intramural Clinical and Biological Research (DICBR), National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland.
Matthew E SloanAddictions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Christina C KennardHuman Psychopharmacology Laboratory, Division of Intramural Clinical and Biological Research (DICBR), National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland.
Shyamala K VenkateshHuman Psychopharmacology Laboratory, Division of Intramural Clinical and Biological Research (DICBR), National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland.
Paule V JosephSection of Sensory Science and Metabolism, DICBR, NIAAA, Bethesda, Maryland.
Melanie L SchwandtOffice of the Clinical Director, DICBR, NIAAA, Bethesda, Maryland.
Marta Yanina PepinoDepartment of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, Illinois.
Nancy DiazgranadosOffice of the Clinical Director, DICBR, NIAAA, Bethesda, Maryland.
Vijay A RamchandaniHuman Psychopharmacology Laboratory, Division of Intramural Clinical and Biological Research (DICBR), National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, Maryland.

Funding

NIAAA Repository/Screening Database Management and ResearchZIAAA000130 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI SCHWANDT, MELANIE · 2017 to 2025
$60.1M
Alcohol Pharmacokinetics and Pharmacodynamics in HumansZ01AA000466 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI RAMCHANDANI, VIJAY ARJUN · 2006 to 2008
$762k
Intramural NIH HHS Z01 AA000466Intramural NIH HHS ZIA AA000130
6 · The paper itself

Abstract

objectiveA low level of response (LR) to alcohol is a known risk factor for alcohol use disorder (AUD). Although higher total body water (TBW) is associated with lower blood alcohol concentrations and reduced responses following alcohol consumption, the relationship between morphometric measures such as body mass index (BMI) and LR is less clear. This study aimed to examine the relationship between BMI and LR to alcohol and the contribution of TBW to this relationship.

methodParticipants (

resultsBMI category was associated with LR, with the normal weight group showing higher responses (lower SRE-Recent scores) to alcohol than the overweight or obese groups. After controlling for TBW, the relationship became nonsignificant. Linear regression models confirmed these findings.

conclusionsHigher BMI is associated with lower LR to alcohol. However, TBW seems to account for this relationship, suggesting that concentrations achieved following alcohol consumption may be the primary determinant of BMI-related differences in LR. Future work should replicate these findings and examine these relationships throughout the life span and in individuals with AUD.

Indexed as

Alcohol DrinkingBody Mass IndexBody WaterEthanolAdultFemaleHumansMaleMiddle AgedYoung AdultEthanol

Identifiers

PMID39812388
PMCPMC12419511

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.