Evidence map›Paper›PMID 39812217›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Constructing Activatable Photosensitizers Using Covalently Modified Mesoporous Silica.

Yan Liu, Xiang Wang, Ben Wang, Zhenni Lu, Changru Wu, Zhanghao He, Libo Jiang, Peng Wei, Tao Yi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  11. Constructing Activatable Photosensitizers Using Covalently Modified Mesoporous Silica.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yan LiuState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai, 201620, China.
Xiang WangState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai, 201620, China.
Ben WangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Zhenni LuState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai, 201620, China.
Changru WuState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai, 201620, China.
Zhanghao HeState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai, 201620, China.
Libo JiangDepartment of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Peng WeiState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai, 201620, China.
Tao YiState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai, 201620, China.ORCID https://orcid.org/0000-0002-3309-8556

Funding

Medical Engineering fund of Fudan University yg2023-27National Key R&D Program of China 2023YFC2308002National Natural Science Foundation of China 22177012National Natural Science Foundation of China 22371038
6 · The paper itself

Abstract

The combination of photosensitizers (PSs) and nanomaterials is a widely used strategy to enhance PS efficacy and broaden their applicability. However, the current nanocarrier-based delivery strategies focus on conventional PSs, neglecting the critical issue of PS phototoxicity. In this study, DHUOCl-25, an activatable PS (aPS) activated by hypochlorous acid, is synthesized by combining a silicon source structure and an activation unit. DHUOCl-25 functions as a silica source for synthesizing activatable mesoporous silica nanostrctures (MSNs) using a standardized protocol, enabling the synthesis of aPS-covalently modified MSNs for a variety of biologic therapeutic applications. On one hand, the resulting nano-aPS maintains aPS functionality for antibacterial application by achieving synergistic antibacterial action via MB PDT and retained cetyltrimethylammonium bromide (CTAB) (antibacterial agent) (DHU-MSNs-2). On the other hand, the nano-aPS exhibits MSN properties for drug loading, facilitating the synergistic integration of photodynamic therapy with chemotherapy (DHU-MSNs-6) of tumors and demonstrating efficacy against the spinal metastases of lung cancer. These results validate this strategy for developing novel aPSs and expanding the application of aPSs and MSNs.

Indexed as

PhotochemotherapyPhotosensitizing AgentsSilicon DioxideAnimalsAnti-Bacterial AgentsCetrimoniumHumansMicePorosityAnti-Bacterial AgentsCetrimoniumPhotosensitizing AgentsSilicon Dioxideactivatable photosensitizercombination therapymesoporous silicaphotodynamic therapy

Identifiers

PMID39812217
PMCPMC11884586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.