Evidence map›Paper›PMID 39812200›Full record

ArticleLa Tunisie medicale2025

Prevalence of pathogenic variants of inborn errors of immunity in critically ill children admitted to the pediatric intensive care unit for sepsis: A Moroccan cohort study.

Ouissal Aissaoui, Abderrahmane Moundir, Asmaa Drissi Boughanbour, Jalila El Bakkouri, Ibtihal Benhsaien, Fatima Ailal, Abdelaziz Chlilek, Emmanuelle Jouanguy, Jean Laurent Casanova, Ahmed Aziz Bousfiha

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Article in La Tunisie medicale, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ouissal AissaouiUniversity Hassan II of Casablanca, Faculty of medicine and pharmacy of Casablanca, Abderrahim HAROUCHI Mother-child hospital, Pediatric Anesthesiology and Intensive Care Unit, Laboratory of clinical immunology, inflammation and allergy (LICIA), Casablanca, Morocco.
Abderrahmane MoundirUniversity Hassan II of Casablanca, Faculty of medicine and pharmacy of Casablanca, Ibn Rochd University hospital, Pediatric Infectious Diseases and Clinical Immunology Unit, Laboratory of clinical immunology, inflammation and allergy (LICIA), Casablanca, Morocco.
Asmaa Drissi BoughanbourUniversity Hassan II of Casablanca, Faculty of medicine and pharmacy of Casablanca, Abderrahim HAROUCHI Mother-child hospital, Laboratory of immunology, Laboratory of clinical immunology, inflammation and allergy, Casablanca, Morocco.
Jalila El BakkouriUniversity Hassan II of Casablanca, Faculty of medicine and pharmacy of Casablanca, Abderrahim HAROUCHI Mother-child hospital, Laboratory of immunology, Laboratory of clinical immunology, inflammation and allergy, Casablanca, Morocco.
Ibtihal BenhsaienUniversity Hassan II of Casablanca, Faculty of medicine and pharmacy of Casablanca, Ibn Rochd University hospital, Pediatric Infectious Diseases and Clinical Immunology Unit, Laboratory of clinical immunology, inflammation and allergy (LICIA), Casablanca, Morocco.
Fatima AilalUniversity Hassan II of Casablanca, Faculty of medicine and pharmacy of Casablanca, Ibn Rochd University hospital, Pediatric Infectious Diseases and Clinical Immunology Unit, Laboratory of clinical immunology, inflammation and allergy (LICIA), Casablanca, Morocco.
Abdelaziz ChlilekUniversity Hassan II of Casablanca, Faculty of medicine and pharmacy of Casablanca, Abderrahim HAROUCHI Mother-child hospital, Pediatric Anesthesiology and Intensive Care Unit, Laboratory of clinical immunology, inflammation and allergy (LICIA), Casablanca, Morocco.
Emmanuelle JouanguyUniversity of Paris, Imagine Institute, Necker Hospital for Sick Children, Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France, St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Jean Laurent CasanovaUniversity of Paris, Imagine Institute, Necker Hospital for Sick Children, Department of Pediatrics, Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Necker Hospital for Sick Children, Paris, France, St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Ahmed Aziz BousfihaUniversity Hassan II of Casablanca, Faculty of medicine and pharmacy of Casablanca, Abderrahim HAROUCHI Mother-child hospital, Pediatric Anesthesiology and Intensive Care Unit, Laboratory of clinical immunology, inflammation and allergy (LICIA), Casablanca, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPediatric sepsis remains a leading cause of morbidity and mortality in Africa. Nearly half of pediatric sepsis deaths occur in previously healthy children. The role of inborn errors of immunity (IEI) in susceptibility to sepsis is yet to be identified and their prevalence amongst previously healthy children admitted to the pediatric intensive care unit (PICU) is unclear. We aimed to assess prevalence of IEI among a cohort of children admitted to the PICU for community acquired sepsis and to describe demographic, microbiological, and genetic features of this cohort.

methodsWe listed a cohort of children admitted to our PICU for sepsis from January 2021 to March 2023. Demographic data was collected, and microbiological tests were performed. Written consent was obtained and whole exome sequencing (WES) was performed after DNA extraction.

resultsThirty cases were included. Mean age at admission was 46 months (1-180), microorganisms were identified in 20 cases (66%). Bacterial sepsis was identified in 8 cases, viral sepsis in 6 cases and fungal sepsis in 2 cases. Mean pediatric sequential sepsis related organ failure assessment (pSOFA) score at admission was 6,46 (2-18). Mechanical ventilation was necessary in 18 cases. Inotropes were used in 17 cases and renal replacement therapy initiated in 3 cases. Pathogenic variants of IEI were identified in 5 out of 30 cases (17%). These variants were identified in the following genes BACH2, TLR7, TINF2, NFK2B and MAGT1. Overall mortality was 50% and mean intensive care unit (ICU) stay was 9,26 (1-60) days.

conclusionPrevalence of pathogenic variants of IEI among children admitted to the PICU for sepsis was 17%. Our study findings support systematic screening of IEI amongst critically ill children admitted to the PICU for sepsis in order to increase our comprehension of sepsis phenotypes and improve outcomes in this group of critically ill children.

Indexed as

SepsisAdolescentChildChild, PreschoolCohort StudiesCritical IllnessFemaleHumansInfantIntensive Care Units, PediatricMaleMoroccoPrevalencechildreninborn errors ofpSOFASepsiswhole exome sequencing

Identifiers

PMID39812200
PMCPMC11906231

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