Evidence map›Paper›PMID 39812178›Full record

ArticleThe Journal of infectious diseases2025

Human HKU1-Reactive CD4 T Cells Are Enriched for Cytolytic Potential That Persists in Older Adults.

Chantelle L White, Katherine A Richards, Nelson Huertas, Jennifer L Nayak, Andrea J Sant

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chantelle L WhiteDavid H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology.
Katherine A RichardsDavid H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology.
Nelson HuertasDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Rochester Medical Center, Rochester, New York.
Jennifer L NayakDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Rochester Medical Center, Rochester, New York.
Andrea J SantDavid H. Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology.ORCID 0000-0001-7176-7426

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00018 · NIAID · UNIVERSITY OF GEORGIA · PI TOMPKINS, S. MARK · 2021 to 2025
$21.6M
The T32 Predoctoral Training Program in Immunology (PTPI)T32AI007285 · NIAID · UNIVERSITY OF ROCHESTER · PI Scott Andrew Gerber, JACQUES Robert · 1986 to 2026
$7.6M
Infection and Immunity: The Pathogenesis of Host-Microbe InteractionsT32AI118689 · NIAID · UNIVERSITY OF ROCHESTER · PI Paul M. Dunman, BRIAN M WARD · 2015 to 2026
$2.5M
National Institute of Allergy and Infectious DiseasesNational Institutes of Health (Pathogenesis T32 5T32AI118689-07National Institutes of Health (Pathogenesis T32 5T32AI7285-34NIAID NIH HHS 75N93021C00018NIAID NIH HHS T32 AI007285NIAID NIH HHS T32 AI118689NIH HHS U01 AI14461602S1
6 · The paper itself

Abstract

The emergence of severe acute respiratory syndrome coronavirus 2 increased interest in cellular immunity established by infections with human coronaviruses (HCoVs). Using peripheral blood mononuclear cells from a cohort of human subjects collected prior to 2019, we assessed the abundance and phenotype of these CD4 T cells using cytokine enzyme-linked immunosorbent spot assays. Unexpectedly, cytotoxic potential was uniquely enriched among HKU1-reactive CD4 T cells, as measured by quantification of granzyme-producing cells. Also, although dramatic losses in HCoV-specific CD4 T-cell abundance for OC43-, NL63-, and 229E-specific cells were observed in older subjects relative to younger adults, HKU1-reactive cells exhibited minimal age-dependent differences in this phenotype.

Indexed as

CD4-Positive T-LymphocytesCOVID-19SARS-CoV-2AdultAgedAged, 80 and overAge FactorsFemaleGranzymesHumansLeukocytes, MononuclearMaleMiddle AgedYoung AdultGranzymesagingCD4 T cellscoronaviruscytotoxic cellshuman immunity

Identifiers

PMID39812178
PMCPMC12247799

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.