Evidence map›Paper›PMID 39812084›Full record

ArticleJournal of the American Chemical Society2025

Synthesis of Chiral Saturated Heterocycles Bearing Quaternary Centers via Enantioselective β-C(sp

Peng Lu, William R Burgenson, Bryan J Simmons, Shuang Liu, Kap-Sun Yeung, Jennifer X Qiao, Jin-Quan Yu

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Intermolecular Enantioselective Nickel-Catalyzed Arylation of Un-Activated C(spAngewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. Article
  4. Enantioselective β-C(spJournal of the American Chemical Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Peng LuDepartment of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0002-8121-8065
William R BurgensonDepartment of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
Bryan J SimmonsResearch & Development, Bristol Myers Squibb, 10300 Campus Point Drive Suite 100, San Diego, California 92121, United States.
Shuang LiuResearch & Development, Bristol Myers Squibb, 10300 Campus Point Drive Suite 100, San Diego, California 92121, United States.ORCID 0000-0001-6341-8103
Kap-Sun YeungResearch & Development, Bristol Myers Squibb, 250 Water Street, Cambridge, Massachusetts 02141, United States.ORCID 0000-0003-3995-6555
Jennifer X QiaoResearch & Development, Bristol Myers Squibb, 250 Water Street, Cambridge, Massachusetts 02141, United States.ORCID 0000-0002-6685-2092
Jin-Quan YuDepartment of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.ORCID 0000-0003-3560-5774

Funding

Ligand-promoted Enantioselective C-H Activation ReactionsR01GM084019 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI YU, JIN-QUAN · 2008 to 2024
$9.5M
NIGMS NIH HHS R01 GM084019
6 · The paper itself

Abstract

The development of catalytic methods for the synthesis of enantiopure saturated heterocycles has been a long-standing challenge in asymmetric catalysis. We describe the first highly enantioselective palladium-catalyzed β

Identifiers

PMID39812084
PMCPMC12349376

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.