Evidence map›Paper›PMID 39812060›Full record

ArticleCombinatorial chemistry & high throughput screening2026

Bushen Daozhuo Granules Alleviate Chronic Non-Bacterial Prostatitis in Rats through p38 MAPK and Akt Signaling Pathways Based on Tandem Mass Tag-Based Quantitative Proteomics and Network Pharmacology Analyses.

Dalin Sun, Yuanyuan Liu, Dong Xing, Dandan Wang, Bin Cai, Zhian Tang, Qinglin Hu, Wenjun Ma, Baofang Jin

Abstract read
PubMed Publisher
In one paragraph

Article in Combinatorial chemistry & high throughput screening, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dalin SunAndrology Department of Integrative Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Yuanyuan LiuSchool of Medicine, Southeast University, Nanjing, China.
Dong XingSchool of Medicine, Southeast University, Nanjing, China.
Dandan WangSchool of Medicine, Southeast University, Nanjing, China.
Bin CaiAndrology Department of Integrative Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Zhian TangDepartment of Traditional Chinese Medicine, Yixing People's Hospital, Yixing, Jiangsu, China.
Qinglin HuDepartment of Urology, Chuzhou Integrated Hospital of Chinese and Western Medicine, Affiliated to Anhui University of Traditional Chinese Medicine, Chuzhou, China.
Wenjun MaDepartment of Urology, Chuzhou Integrated Hospital of Chinese and Western Medicine, Affiliated to Anhui University of Traditional Chinese Medicine, Chuzhou, China.
Baofang JinAndrology Department of Integrative Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.

Funding

National Natural Science Foundation of China 81874472, 81774315, 82074440
6 · The paper itself

Abstract

introductionThe traditional Chinese medicine formula, Bushen Daozhuo Granules (BSDZG), is used to treat chronic non-bacterial prostatitis (CNP) clinically. However, its mechanism of action is unclear. The aim of our study was to determine the effect of BSDZG on CNP and its underlying mechanisms.

methodsMale Wistar rats were randomly assigned to control, CNP, and BSDZG groups. CNP was induced using purified prostaglandin solution and Freund's complete adjuvant, after which the BSDZG group received 1.54 g/kg/d of BSDZG for 30 days. Prostate tissues were used to determine apoptosis and inflammatory cytokines. The herb-composition-target network and functional signaling pathways were built using a network pharmacology approach, which was also confirmed

resultsTreatment with BSDZG significantly alleviated the histopathological lesions, inflammation, and apoptosis in the prostate of CNP rats. The herb-composition-target network comprising 42 active compounds and 32 targets of 11 herbs was illustrated, and KEGG pathways analysis identified the Akt and MAPK pathways as related to the effects of BSDZG. Phosphorylation of p38 MAPK, NF-κB, and Bax expression was significantly enhanced and phosphorylated Akt and Bcl-2 levels were decreased in CNP rats, which could be reversed by BSDZG.

conclusionThis study presented for the first time that BSDZG effectively alleviated CNP symptoms in rats and elucidated the underlying mechanisms mediated by the Akt and MAPK pathways, providing the theoretical basis for the clinical use and promotion of BSDZG.

Indexed as

Drugs, Chinese Herbalp38 Mitogen-Activated Protein KinasesProstatitisProto-Oncogene Proteins c-aktAnimalsApoptosisMaleNetwork PharmacologyProteomicsRatsRats, WistarSignal TransductionTandem Mass SpectrometryDrugs, Chinese Herbalp38 Mitogen-Activated Protein KinasesProto-Oncogene Proteins c-aktAktanti-apoptoticanti-inflammatoryMAPKNF-κBTraditional Chinese medicine

Identifiers

PMID39812060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.