Evidence map›Paper›PMID 39811957›Full record

ArticleAnnals of surgery2026

Does Parathyroid Autotransplantation Prevent Hypoparathyroidism After Thyroid Surgery?

Julia Adriana Kasmirski, Ashba Allahwasaya, Christopher Wu, Zhixing Song, Ramsha Akhund, Sanjana Balachandra, Marshall Chandler McLeod, Andrea Gillis, Jessica Fazendin, Brenessa Lindeman and 1 more

Abstract readClinical StudyComparative Study
In one paragraph

Article in Annals of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Julia Adriana KasmirskiDepartment of Surgery, University of Alabama, Birmingham, Birmingham, AL.
Ashba AllahwasayaORCID 0009-0000-7638-0562
Christopher Wu
Zhixing Song
Ramsha Akhund
Sanjana Balachandra
Marshall Chandler McLeod
Andrea Gillis
Jessica Fazendin
Brenessa Lindeman
Herbert Chen

Funding

Surgical Oncology Research Training ProgramT32CA229102 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI HERBERT CHEN · 2018 to 2026
$3.2M
NCI NIH HHS T32 CA229102
6 · The paper itself

Abstract

objectiveTo assess the impact of parathyroid gland autotransplantation on the restoration of parathyroid function in patients who are hypoparathyroid after thyroidectomy.

backgroundHypoparathyroidism postthyroidectomy arises when all parathyroid glands are devascularized or injured. Autotransplantation of compromised parathyroids aims to preserve their function and prevent permanent hypoparathyroidism. Despite routine use, comprehensive evidence on the efficacy of parathyroid autotransplantation remains limited.

methodsA retrospective analysis was conducted on 549 patients who underwent total or completion thyroidectomy from December 2015 to June 2023. Surgical outcomes of patients with and without parathyroid autotransplantation were compared. A subgroup analysis included patients with postanesthesia care unit (PACU) parathyroid hormone (PTH) levels below 10 units. Statistical analyses included the χ 2 test and multivariable analysis.

resultsOf the 549 patients, 152 (27.7%) had parathyroid autotransplantation and 397 (72.3%) did not. The groups were similar in demographics and underlying thyroid etiologies. No significant difference was found in intraoperative parathyroid identification rates ( P = 0.25). Postoperatively, autotransplanted patients had a higher incidence of transient symptomatic hypocalcemia at 2 weeks (38.0% vs 19.3%, P < 0.001). Multivariable regression showed a higher frequency of postoperative transient hypocalcemia with autotransplantation (incidence rate ratio = 1.90, 95% CI: 1.42-2.54, P < 0.001). Among patients with PACU PTH <10 units, recovery rates of parathyroid function were similar between treatment groups (82.2% vs 82.5%, P = 0.46). Long-term follow-up showed a comparable low incidence of parathyroid insufficiency in both groups (5.3% vs 3.8%, P = 0.46).

conclusionsParathyroid autotransplantation does not enhance recovery in hypoparathyroid patients postthyroidectomy and does not significantly alter outcomes among patients with PACU PTH <10.

Indexed as

HypoparathyroidismParathyroid GlandsPostoperative ComplicationsThyroidectomyAdultFemaleFollow-Up StudiesHumansHypocalcemiaIncidenceMaleMiddle AgedProspective StudiesRecovery of FunctionRetrospective StudiesTransplantation, Autologoushypoparathyroidismlong-term parathyroid recoveryparathyroid autotransplantationparathyroid function restorationparathyroid gland preservationpostoperative hypocalcemiathyroidectomy

Identifiers

PMID39811957
PMCPMC12276954

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.