Evidence map›Paper›PMID 39811891›Full record

ArticleInternational forum of allergy & rhinology2025

Unilateral Versus Bilateral Endoscopic Resection of Olfactory Neuroblastoma: Pooled Analysis From Prospective and Retrospective Multicenter Data.

Arash Abiri, Theodore V Nguyen, Haidee Chen, Elise Krippaehne, David K Lerner, Arifeen S Rahman, Pooya Roozdar, Brandon R Rosvall, Michael Sabbaj, Alan D Workman and 26 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International forum of allergy & rhinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Arash AbiriDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Orange, California, USA.ORCID 0000-0003-2656-1060
Theodore V NguyenDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Orange, California, USA.ORCID 0000-0002-3416-5976
Haidee ChenDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, California, USA.ORCID 0000-0003-2723-9313
Elise KrippaehneDepartment of Otolaryngology-Head & Neck Surgery, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0009-0006-2536-5710
David K LernerDepartment of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Arifeen S RahmanDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0002-3322-5287
Pooya RoozdarDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.
Brandon R RosvallDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Michael SabbajDepartment of Otolaryngology-Head & Neck Surgery, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Alan D WorkmanDepartment of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Shannon WuDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.
Nithin D AdappaDepartment of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Daniel M BeswickDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, California, USA.ORCID 0000-0001-8612-5442
Eugene H ChangDepartment of Otolaryngology-Head and Neck Surgery, University of Arizona, Tucson, Arizona, USA.
Michael T ChangDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0001-9519-5880
Garret ChobyDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-3745-2727
Jacob G EideDepartment of Otolaryngology-Head & Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Jennifer E DouglasDepartment of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-3634-2067
Mathew GeltzeilerDepartment of Otolaryngology-Head & Neck Surgery, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA.
Michael A KohanskiDepartment of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Peter H HwangDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0002-0786-4675
Christopher H LeDepartment of Otolaryngology-Head and Neck Surgery, University of Arizona, Tucson, Arizona, USA.
Jivianne T LeeDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Jayakar V NayakDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0003-4454-0861
James N PalmerDepartment of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Zara M PatelDepartment of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0003-2072-982X
Carlos D Pinheiro-NetoDepartment of Otolaryngology-Head & Neck Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Adam C ResnickDepartment of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Timothy L SmithDepartment of Otolaryngology-Head & Neck Surgery, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0002-6424-7083
Carl H SnydermanDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-8920-4522
Maie A St JohnDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Phillip B StormDepartment of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jeffrey D SuhDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Marilene B WangDepartment of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Eric W WangDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-1180-5854
Edward C KuanDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, Orange, California, USA.ORCID 0000-0003-3475-0718

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
NIGMS NIH HHS T32 GM008620NIH HHS T32GM008620
6 · The paper itself

Abstract

backgroundOlfactory neuroblastoma (ONB) is a rare sinonasal malignancy primarily treated with surgery. For tumors arising from the olfactory area, traditional treatment involves transcribriform resection of the anterior cranial fossa. Surgery can be performed with unilateral or bilateral resection depending on extent of involvement; however, there are currently no studies comparing outcomes between the two.

methodsProspective and retrospective data on primary ONB patients were collected from a multicenter registry involving eight academic sites. Propensity score matching (PSM) was used to create patient cohorts with similar baseline characteristics. Cox proportional hazards and Kaplan Meier analyses assessed overall survival (OS). Logistic regression assessed associations between extent of resection (unilateral versus bilateral) and tumor recurrence or postoperative cerebrospinal fluid (CSF) leak.

resultsA total of 187 ONB patients (47.6% female) with an average age of 53.6 ± 15.1 years were analyzed. Most tumors were unilateral (81.3%) and predominantly Kadish C (58.3%) or Hyams II (55.8%). Overall, 56.7% of patients underwent bilateral resection. Fifty-four patients experienced tumor recurrence and nine had postoperative CSF leaks. Following PSM (n = 45/group), extent of resection was not associated with mortality (hazard ratio [HR] 1.73; p = 0.407) or OS (p = 0.400). There was no association between extent of resection and recurrence (odds ratio [OR] 0.90; p = 0.814) or postoperative CSF leak (OR 1.54; p = 0.647).

conclusionsFor ONB tumors where unilateral resection may be feasible and oncologically sound, the decision for unilateral versus bilateral resection showed no significant effect on survival, recurrence, or postoperative CSF leak. Oncologic outcomes may be comparable when resection is tailored to individual patient and tumor characteristics.

Indexed as

EndoscopyEsthesioneuroblastoma, OlfactoryNasal CavityNose NeoplasmsAdultAgedCerebrospinal Fluid LeakFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalProspective StudiesRetrospective StudiesTreatment Outcomeendoscopic surgeryesthesioneuroblastomaolfactory neuroblastomaoutcomesresectionsurvival

Identifiers

PMID39811891
PMCPMC12135456

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