Evidence map›Paper›PMID 39811762›Full record

ArticleJID innovations : skin science from molecules to population health2025

Creating an Extremely Long-lasting Neuroischemic Wound Model.

Sufan Chien, Harshini Sarojini, Arezoo Rajaee, Mohammad Bayat, Samson Chien, Girish Kotwal

Abstract read
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sufan ChienDepartment of Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Harshini SarojiniDepartment of Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Arezoo RajaeeDepartment of Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Mohammad BayatDepartment of Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Samson ChienDepartment of Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Girish KotwalDepartment of Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA.

Funding

Developing a new DFU dressingR44DK133065 · NIDDK · NOVERATECH, LLC · PI CHIEN, SUFAN · 2022 to 2023
$1.7M
A New Technique for Diabetic Foot UlcersR44DK105692 · NIDDK · NOVERATECH, LLC · PI CHIEN, SUFAN · 2016 to 2017
$1.5M
A new technique for diabetic foot ulcersR43DK105692 · NIDDK · NOVERATECH, LLC · PI CHIEN, SUFAN · 2015 to 2015
$275k
TOWARDS A UNIVERSAL CHRONIC WOUND MODELR43OD021317 · OD · NOVERATECH, LLC · PI CHIEN, SUFAN · 2015 to 2015
$243k
NIDDK NIH HHS R43 DK105692NIDDK NIH HHS R44 DK105692NIDDK NIH HHS R44 DK133065NIH HHS R43 OD021317
6 · The paper itself

Abstract

In wound study and dressing development, a lack of a suitable animal model that can recapitulate the complex pathophysiology of human chronic wounds has been a major hurdle. Chronic wounds are defined as wounds that heal with a significant delay, usually over a period >2-3 months, but no current animal wound model has such a longischemia. After a longexploration, our group has developed an animal wound model with ischemia and nerve damage lasting for at least 6 months. This model can be easily combined with other conditions such as diabetes and aging for wound mechanistic study and critical testing of dressings. This report presents the method that has significant utility in evaluating therapies that could become the future standard for screening all new wound dressings.

Indexed as

Animal modelLong termNeuroischemiaRabbitWound

Identifiers

PMID39811762
PMCPMC11728989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.