Break through the mold: Hyper-IgE syndrome as a vehicle for invasive aspergillosis.

Joseph Nordin, Stephen Smetana, Rachel Johnson, Angela Bartosiak, Nicholas Nassif

Abstract readCase Reports

In one paragraph

Article in Respiratory medicine case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Hyper IgE Syndrome: Bridging the Gap Between Immunodeficiency, Atopy, and Allergic Diseases.Current allergy and asthma reports · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joseph NordinAurora Health Care, 945 N, 12th Street, 5th Floor, Internal Medicine Clinic, Milwaukee, WI, USA.

Stephen SmetanaAurora Health Care, 945 N, 12th Street, 5th Floor, Internal Medicine Clinic, Milwaukee, WI, USA.

Rachel JohnsonAurora Health Care, 945 N, 12th Street, 5th Floor, Internal Medicine Clinic, Milwaukee, WI, USA.

Angela BartosiakAurora Health Care, 945 N, 12th Street, 5th Floor, Internal Medicine Clinic, Milwaukee, WI, USA.

Nicholas NassifDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperimmunoglobulin E syndrome (HIGES) is a rare immunodeficiency characterized by high levels of immunoglobulin E (IgE) in the setting of various clinical features such as cutaneous candidiasis, asthma, recurrent rashes, and fungal infections. This case describes a 70-year-old male with cachexia and dyspnea found to have a cavitary lesion and aspergilloma, with remarkably high IgE and positive 1,3-β-D-glucan and Aspergillus testing. Herein, we describe the aforementioned case, review the available literature, and hypothesize the connection between invasive fungal infections and HIGES. We hope this discussion helps highlight the importance of a broad differential in chronic dyspnea, including infectious etiologies, and allows for a better understanding of immunologic labs in the setting of fungal infections.

Identifiers

PMID39811720

DOI10.1016/j.rmcr.2024.102149

PMCPMC11730267

What OpenQuestion holds

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LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.