Evidence map›Paper›PMID 39811665›Full record

ArticleiScience2025

Monocytes generated by interleukin-6-treated human hematopoietic stem and progenitor cells secrete calprotectin that inhibits erythropoiesis.

Valentine Marchand, Lucie Laplane, Louis Valensi, Isabelle Plo, Marine Aglave, Aymeric Silvin, Florence Pasquier, Françoise Porteu, William Vainchenker, Dorothée Selimoglu-Buet and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Valentine MarchandINSERM U1287, Université Paris-Saclay, Gustave Roussy Cancer Center, Villejuif, France.
Lucie LaplaneINSERM U1287, Université Paris-Saclay, Gustave Roussy Cancer Center, Villejuif, France.
Louis ValensiINSERM U1287, Université Paris-Saclay, Gustave Roussy Cancer Center, Villejuif, France.
Isabelle PloINSERM U1287, Université Paris-Saclay, Gustave Roussy Cancer Center, Villejuif, France.
Marine AglaveAMMICa, INSERM US 23, CNRS UMS 3655, Gustave Roussy Cancer Center, Villejuif, France.
Aymeric SilvinINSERM U1108, Gustave Roussy Cancer Center, Villejuif, France.
Florence PasquierDepartment of Hematology, Gustave Roussy Cancer Center, Villejuif, France.
Françoise PorteuINSERM U1287, Université Paris-Saclay, Gustave Roussy Cancer Center, Villejuif, France.
William VainchenkerINSERM U1287, Université Paris-Saclay, Gustave Roussy Cancer Center, Villejuif, France.
Dorothée Selimoglu-BuetINSERM U1287, Université Paris-Saclay, Gustave Roussy Cancer Center, Villejuif, France.
Nathalie DroinINSERM U1287, Université Paris-Saclay, Gustave Roussy Cancer Center, Villejuif, France.
Hana RaslovaINSERM U1287, Université Paris-Saclay, Gustave Roussy Cancer Center, Villejuif, France.
Virginie MarcelInserm U1052, CNRS UMR5286 Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Jean-Jacques DiazInserm U1052, CNRS UMR5286 Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Michaela FontenayUniversité Paris Cité, Institut Cochin, CNRS UMR 8104, INSERM U1016, Paris, France.
Eric SolaryINSERM U1287, Université Paris-Saclay, Gustave Roussy Cancer Center, Villejuif, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elevated circulating levels of calprotectin (CAL), the S100A8/A9 heterodimer, are biomarkers of severe systemic inflammation. Here, we investigate the effects of CAL on early human hematopoiesis. CAL demonstrates limited impact on gene expression in stem and progenitor cells, in contrast with interleukin-6 (IL6), which promotes the expression of the

Indexed as

Cell biologyPathology

Identifiers

PMID39811665
PMCPMC11732210

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.