Evidence map›Paper›PMID 39811655›Full record

ArticleiScience2025

ETV2/ER71 regulates hematovascular lineage generation and vascularization through an H3K9 demethylase, KDM4A.

Min Seong Kim, Raham Lee, Dong Hun Lee, Heesang Song, Taekyung Ha, Joo Kyung Kim, Bum-Yong Kang, Karl Agger, Kristian Helin, Donghyun Shin and 2 more

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Min Seong KimDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Raham LeeDepartment of Molecular and Cellular Physiology, Louisiana State University Health Science Center, Shreveport, LA, USA.
Dong Hun LeeDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Heesang SongDepartment of Biochemistry and Molecular Biology, Chosun University School of Medicine, Gwangju, Republic of Korea.
Taekyung HaDepartment of Molecular and Cellular Physiology, Louisiana State University Health Science Center, Shreveport, LA, USA.
Joo Kyung KimDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Bum-Yong KangDepartment of Medicine, Emory University School of Medicine, and Atlanta VA HCS, Atlanta, GA, USA.
Karl AggerBiotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.
Kristian HelinBiotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.
Donghyun ShinDepartment of Agricultural Convergence Technology, Jeonbuk National University, Jeonju, Republic of Korea.
Yunhee KangDepartment of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.
Changwon ParkDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Mechanisms of ER71/ETV2-regulated VascularizationR01HL119291 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PARK, CHANGWON · 2013 to 2022
$3.2M
The Role of PPARy in the Pathogenesis and Therapy of Sickle Cell Disease-Pulmonary HypertensionR01HL133053 · NHLBI · EMORY UNIVERSITY · PI KANG, BUM-YONG · 2017 to 2020
$1.3M
NCI NIH HHS P30 CA008748NHLBI NIH HHS R01 HL119291NHLBI NIH HHS R01 HL133053
6 · The paper itself

Abstract

ETV2/ER71, an ETS (E-twenty six) transcription factor, is critical for hematopoiesis and vascular development. However, research about the molecular mechanisms behind ETV2-mediated gene transcription is limited. Herein, we demonstrate that ETV2 and KDM4A, an H3K9 demethylase, regulate hematopoietic and endothelial genes.

Indexed as

Cell biologyMolecular biology

Identifiers

PMID39811655
PMCPMC11732216

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.