Evidence map›Paper›PMID 39811642›Full record

ArticleiScience2025

Mitoregulin self-associates to form likely homo-oligomeric pore-like complexes.

Connor R Linzer, Colleen S Stein, Nathan H Witmer, Zhen Xu, Nicholas J Schnicker, Ryan L Boudreau

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Connor R LinzerDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Colleen S SteinDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Nathan H WitmerDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Zhen XuProtein and Crystallography Facility, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Nicholas J SchnickerProtein and Crystallography Facility, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Ryan L BoudreauDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Funding

Predoctoral Training in the Pharmacological SciencesT32GM067795 · NIGMS · UNIVERSITY OF IOWA · PI STRACK, STEFAN · 2004 to 2021
$3.4M
The physiologic and genomic relevance of mitoregulin in ischemic heart failureR01HL150557 · NHLBI · UNIVERSITY OF IOWA · PI BOUDREAU, RYAN L · 2020 to 2023
$1.5M
NHLBI NIH HHS R01 HL150557NIGMS NIH HHS T32 GM067795
6 · The paper itself

Abstract

We and others previously found that a misannotated long noncoding RNA encodes for a conserved mitochondrial transmembrane microprotein named Mitoregulin (Mtln). Beyond an established role for Mtln in lipid metabolism, Mtln has been shown to broadly influence mitochondria, boosting respiratory efficiency and Ca

Indexed as

Cell biologyStructural biology

Identifiers

PMID39811642
PMCPMC11732159

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.