Evidence map›Paper›PMID 39811610›Full record

ArticleMaterials today. Bio2025

The adhesion mechanism of mucoadhesive tablets with dissimilar chain flexibility on viscoelastic hydrogels.

Gergely Stankovits, Kata Szayly, Dorián László Galata, János Móczó, András Szilágyi, Benjámin Gyarmati

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PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gergely StankovitsDepartment of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111, Budapest, Hungary.
Kata SzaylyDepartment of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111, Budapest, Hungary.
Dorián László GalataDepartment of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111, Budapest, Hungary.
János MóczóDepartment of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111, Budapest, Hungary.
András SzilágyiDepartment of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111, Budapest, Hungary.
Benjámin GyarmatiDepartment of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111, Budapest, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucosal membranes with strong variability in their viscoelastic properties line numerous organs and are often targeted by mucoadhesive formulations, e.g., highly swellable hydroxypropylmethylcellulose (HPMC) and slightly cross-linked poly(acrylic acid) (PAA) tablets. Although the factors determining the strength of mucoadhesion are hierarchical and affected by both reversible and irreversible processes, the currently available strategies generally view mucoadhesion as the individual performance of the mucoadhesive excipient. We propose an integrated concept that considers the viscoelasticity and tensile properties of both the adhesive interphase and the bulk phases. To reduce the complexity of the mucosal membrane and eliminate the effect of specific macromolecular interactions, we studied the adhesion on mucosa-mimetic freeze/thawed (FT) poly(vinyl alcohol) (PVA) hydrogels. Their viscoelastic properties were controlled by the number of FT cycles and the polymer concentration. The adhesive strength of HPMC tablets displayed a pronounced dependence on the viscoelasticity of PVA gels, explained by the limited chain flexibility and interpenetration of HPMC, resulting in the formation of a thin the adhesive interphase compared to PAA. We recognized scaling laws between toughness and strength for tensile and adhesive properties as well as general correlations between viscoelastic and adhesive properties, which can aid the more rational design of both mucoadhesive formulations and mucosa-mimetic materials.

Indexed as

Chain entanglementsChain flexibilityCohesive failureOscillatory shear rheologyRelaxation time spectraSoft materials

Identifiers

PMID39811610
PMCPMC11732199

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.