Evidence map›Paper›PMID 39811586›Full record

ReviewJPRAS open2025

From Lab to Limb: Unraveling Translational Insights and Significance of Animal Models in Lower Extremity Transplantation.

Yalcin Kulahci, Naga Anvesh Kodali, Zeynep Demir, Omer Dirican, Bedreddin Sazoglu, Ramu Janarthanan, Fatih Zor, Vijay S Gorantla

Abstract readReview
In one paragraph

Review in JPRAS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yalcin KulahciDepartment of Surgery, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
Naga Anvesh KodaliDepartment of Surgery, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
Zeynep DemirDepartment of Surgery, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
Omer DiricanDepartment of Surgery, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
Bedreddin SazogluDepartment of Surgery, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
Ramu JanarthananDepartment of Surgery, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.
Fatih ZorDepartment of Plastic Surgery, Indiana University, Indianapolis, Indiana, USA.
Vijay S GorantlaDepartment of Surgery, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advancements in medicine throughout the twentieth century have been largely attributed to animal studies. The initial step in researching an animal disease is to establish a model closely resembling the clinical circumstances in humans. Consequently, an excellent animal model is essential for almost any experimental research. The aim of this review is to evaluate the current research on animal models for lower extremity transplantation (LET) and determine how pertinent and significant these models are for therapeutic settings. To bring the reader up to date from an allotransplantation standpoint, we also review, assess, and highlight the noteworthy and intriguing results of the clinical cases performed so far and various animal models. The discussion of their clinical applicability and practicality in the present and future has shed light on the experience with vascularized composite allotransplantation (VCA) around the globe.

Indexed as

Animal modelsLETLower extremity transplantationVascularized composite allotransplantationVCA

Identifiers

PMID39811586
PMCPMC11730959

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.