ArticleBioactive materials2025
A self-hygroscopic, rapidly self-gelling polysaccharide-based sponge with robust wet adhesion for non-compressible hemorrhage control and infected wounds healing.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Bioinspired All-in-One Wound Dressing: Integrating Photothermal-Enhanced Drainage and Strain-Sensing Monitoring for Intelligent Healing.Advanced healthcare materials · 2026Article
- Bench-to-Bedside Translation of Self-Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Glucose-responsive nanozyme hydrogel for glycemic control and catalytic anti-infective therapy in diabetic wound healing.Materials today. Bio · 2025Article
- Immunoregulatory electrospinning fiber mediates Macrophage energy metabolism reprogramming to promote burn wound healing.Materials today. Bio · 2025Article
- Lipoic acid-kaempferol hydrogel loaded with Typhaneoside for sutureless wound closure, hemostasis, and healing of diabetic infected wounds.Materials today. Bio · 2025Article
- A Single-Component Adhesive Sponge Based on Blood-Triggered and Autopenetrative Adhesion for Robust Vascular Closure.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Influence of Mucoadhesive Polymers on Physicochemical Features and Biocompatibility of Collagen Wafers.ACS polymers Au · 2025Article
- Novel Platelet-Like PLGA-PSP Nanoparticles Based on Platelet-Specific Peptides Alleviated Traumatic Hemorrhage.International journal of nanomedicine · 2025Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uncontrollable non-compressible hemorrhage and traumatic infection have been major causes of mortality and disability in both civilian and military populations. A dressing designed for point-of-care control of non-compressible hemorrhage and prevention of traumatic infections represents an urgent medical need. Here, a novel self-gelling sponge OHN@ε-pL is developed, integrating N-succinimidyl ester oxidized hyaluronic acid (OHN) and ε-poly-L-lysine (ε-pL). Upon application to the wound site, the sponge can rapidly absorb interfacial fluids and undergo a phase transition from sponge to gel. The transformed gel facilitates robust tissue adhesion and achieves synergistic hemostasis by enriching coagulation factors within the sponge phase and providing a barrier effect in the gel phase. The in vitro and in vivo studies revealed that the optimized OHN@ε-pL
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.