Evidence map›Paper›PMID 39811454›Full record

ArticleFrontiers in neurology2024

Decreased neuronal excitability in hypertriglyceridemia hamsters with acute seizures.

Qiuyue Shen, Nana Liu, Yuwu Jiang, Lili Liu, Xinlin Hou

Abstract read
In one paragraph

Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qiuyue Shen *Department of Pediatrics, Peking University First Hospital, Beijing, China.
Nana Liu *Department of Pediatrics, Peking University First Hospital, Beijing, China.
Yuwu JiangDepartment of Pediatrics, Peking University First Hospital, Beijing, China.
Lili LiuDepartment of Pediatrics, Peking University First Hospital, Beijing, China.
Xinlin HouDepartment of Pediatrics, Peking University First Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Neonatal seizures are the most common clinical manifestation of neurological dysfunction in newborns, with an incidence ranging from 1 to 5‰. However, the therapeutic efficacy of current pharmacological treatments remains suboptimal. This study aims to utilize genetically modified hamsters with hypertriglyceridaemia (HTG) to investigate the effects of elevated triglycerides on neuronal excitability and to elucidate the underlying mechanisms. The ultimate goal is to identify novel therapeutic targets for the treatment of neonatal seizures. Methods: Acute seizure models were established both Results: Conclusion: Hypertriglyceridemic

Indexed as

hypertriglyceridemiapalmitoylation modificationseizuretransient outward K+ currentsZDHHC14

Identifiers

PMID39811454
PMCPMC11730077

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.