Kikuchi-Fujimoto disease associated optic neuropathy in an adolescent.

Justin H Cheong, Zacharia Nayer, Jeffrey G Odel

Abstract readCase Reports

In one paragraph

Article in American journal of ophthalmology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

3 authors.

Justin H CheongColumbia University Vagelos College of Physicians and Surgeons, 104 Haven Avenue, New York, NY, 10032, USA.

Zacharia NayerDepartment of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York Presbyterian Hospital, New York, NY, USA.

Jeffrey G OdelDepartment of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York Presbyterian Hospital, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: We present a case of Kikuchi-Fujimoto Disease (KFD) associated with bilateral optic neuropathy progressing to vision loss. Observations: A 17-year-old male was referred for bilateral optic nerve pallor. Eight years prior, he was diagnosed with KFD after workup for lymphadenopathy and treated with prednisolone acutely followed by long-term Plaquenil. He had reduced vision shortly after the diagnosis of KFD. Visual acuity was 20/50 OD and 20/250 OS, with pinhole to 20/40 OD and 20/70 OS. Comprehensive laboratory workup for infectious and autoimmune etiologies, including systemic lupus erythematosus (SLE), were negative. Magnetic resonance imaging (MRI) showed bilateral optic nerve atrophy and atrophy of the optic chiasm. The patient trialed B-complex vitamins with no improvement and continued to worsen with acute decrease in vision to no light perception OD at three-year follow-up. Treatment remained supportive. Conclusions and Importance: This is a case of bilateral KFD-associated optic neuropathy in an adolescent. Unlike previously reported cases, the patient experienced acute vision loss rather than full recovery of visual acuity after treatment. Ophthalmologists should be aware of the rare but serious association of optic neuritis and KFD.

Indexed as

Histiocytic necrotizing lymphadenitisKikuchi diseaseKikuchi-Fujimoto diseaseOptic neuritisOptic neuropathySystemic lupus erythematosus

Identifiers

PMID39811415

DOI10.1016/j.ajoc.2024.102242

PMCPMC11732578

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