Evidence map›Paper›PMID 39811412›Full record

ReviewLeukemia research reports2025

Targeting menin for precision therapy in high-risk acute myeloid leukemia.

Abdur Jamil, Zaheer Qureshi, Zain Mary El-Amir, Gillian Kupakuwana-Suk, Hamzah Akram, Mohsin Ahmad, Eric Huselton

Abstract readReview
In one paragraph

Review in Leukemia research reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abdur JamilDepartment of Medicine, Samaritan Medical Centre Watertown, NY, USA.
Zaheer QureshiThe Frank H. Netter M.D. School of Medicine at Quinnipiac University, Bridgeport, Connecticut, USA.
Zain Mary El-AmirUniversity of Michigan, Ann Arbor, MI, USA.
Gillian Kupakuwana-SukLeukemia Fellowship Program at The Ottawa Hospital Division of Hematology Department of Medicine University of Ottawa, Ottawa, Canada.
Hamzah AkramHamilton Health Sciences, Hamilton, Ontario, Canada.
Mohsin AhmadCHRISTUS Southeast Texas - St. Elizabeth Hospital, Beaumont, Texas, USA.
Eric HuseltonUniversity of Rochester, Department of Hematology/Oncology, Rochester, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This mini-review provides an overview of the current evidence for Revumenib, a first-in-class menin inhibitor, in treating AML with KMT2A rearrangements or NPM1 mutations. This therapy represents a promising advancement by selectively disrupting leukemogenic pathways. Summary: The clinical promise of Revumenib in genetically defined AML highlights its potential role in shaping the future treatment landscape. This mini-review underscores the need for ongoing trials to define optimal dosing, safety protocols, and combination therapies, with the ultimate goal of establishing Revumenib as a standard of care for high-risk AML subsets.

Indexed as

Acute myeloid leukemiaKMT2AMenin inhibition therapyRevumenib

Identifiers

PMID39811412
PMCPMC11732178

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.