Evidence map›Paper›PMID 39811346›Full record

ArticleHeliyon2025

Achieving enhanced stabilization and controlled release of curcumin

Majid Moussaei, Ebrahim Tajik, Vahid Haddadi-Asl, S Ali Mazloumi, Helia Heydarinasab, Elahe Abdollahi, Fatemeh Haj-Sadeghi, Hanie Ahmadi, Mohammad Reza Gholizadeh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Majid MoussaeiDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
Ebrahim TajikDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
Vahid Haddadi-AslDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
S Ali MazloumiDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
Helia HeydarinasabDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
Elahe AbdollahiDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
Fatemeh Haj-SadeghiDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
Hanie AhmadiDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.
Mohammad Reza GholizadehDepartment of Polymer Engineering and Color Technology, Amirkabir University of Technology, P.O. Box 15875-4413, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Development of efficient drug delivery systems remains a critical challenge in pharmaceutical applications, necessitating novel approaches to improve drug loading and release profiles. In this study, a novel method is presented for fabricating crosslinked polydopamine particles (XPDPs) using a water/water Pickering emulsion system. The emulsion is composed of poly(ethylene glycol) and dextran, stabilized by polydopamine (PDA) particles. This method yields XPDPs with a mean particle size of 0.55 μm, significantly smaller than PDA particles (1.025 μm), resulting in a higher surface area favorable for drug loading. The adsorption mechanism involves electron sharing and covalent bonding between the carrier and drug molecules. The adsorption, release, and drug delivery kinetics of the XPDPs are compared with those of the non-crosslinked PDA particles. The results demonstrate that XPDPs exhibit improved adsorption properties due to their crosslinked structure and increased positive charge due to presence of secondary amines. During a 28-h period, curcumin release from PDA declines from around 80 %-40 %, while for XPDA, it decreases from approximately 60 %-35 % as the pH shifts from 7.4 to 5. While PDA particles display a burst release profile, XPDPs show a more gradual and sustained release, attributed to their enhanced structural stability. Molecular simulations were conducted to estimate the solubility parameters, confirming the compatibility between PDA and dextran for effective drug loading.

Indexed as

Controlled drug releaseCurcuminMolecular simulationPolydopamine

Identifiers

PMID39811346
PMCPMC11729636

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.