Evidence map›Paper›PMID 39811317›Full record

ArticleHeliyon2025

TRIM26 exacerbates pathological cardiac hypertrophy by activating TAK1.

Xiaochuang Xia, Huajing Shan, Zhaoxia Jin, Tengfei Ma, Yemao Liu, Jianqing Zhang, Han Tian, Bizhen Dong, Chengsheng Xu, Shaoze Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. RASSF1A and its epigenetic dysregulation in genitourinary cancer: a current update.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaochuang XiaDepartment of Cardiology, Huanggang central Hospital of Yangtze University, Huanggang, China.
Huajing ShanDepartment of Cardiology, Huanggang central Hospital of Yangtze University, Huanggang, China.
Zhaoxia JinDepartment of Cardiology, Huanggang central Hospital of Yangtze University, Huanggang, China.
Tengfei MaDepartment of Neurosurgery, Huanggang central Hospital of Yangtze University, Huanggang, China.
Yemao LiuDepartment of Cardiology, Huanggang central Hospital of Yangtze University, Huanggang, China.
Jianqing ZhangDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Han TianDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Bizhen DongHuanggang Institute of Translational Medicine, Huanggang, China.
Chengsheng XuDepartment of Cardiology, Huanggang central Hospital of Yangtze University, Huanggang, China.
Shaoze ChenDepartment of Cardiology, Huanggang central Hospital of Yangtze University, Huanggang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pathological myocardial hypertrophy can induce heart failure with high mortality, it is necessary to explore its pathogenesis. Tripartite motif-containing 26 (TRIM26) belongs to the multidomain E3 ubiquitin ligase family. We observed increased expression of TRIM26 in the myocardium of C57BL/6 mice subjected to transverse aortic constriction (TAC) surgery and neonatal rat cardiomyocytes (NRCMs) treated with phenylephrine (PE). To evaluate the role of TRIM26 in pathological cardiac hypertrophy, we generated

Indexed as

Pathological cardiac hypertrophyTGF-Beta activated kinase 1Transverse aortic constrictionTripartite motif containing 26

Identifiers

PMID39811317
PMCPMC11729661

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.