Evidence map›Paper›PMID 39811302›Full record

ReviewHeliyon2025

Exploring perinatal mesenchymal stromal cells as a potential therapeutic strategy for rheumatoid arthritis.

Stefano Alivernini, Alice Masserdotti, Marta Magatti, Anna Cargnoni, Andrea Papait, Antonietta R Silini, Jacopo Romoli, Sara Ficai, Clara Di Mario, Elisa Gremese and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Stefano AliverniniImmunology Research Core Facility, Gemelli Science and Technology Park (GSTeP), Fondazione Policlinico Universitario A, Gemelli IRCCS, Rome, Italy.
Alice MasserdottiDepartment of Life Science and Public Health, Università Cattolica Del Sacro Cuore, Rome, Italy.
Marta MagattiCentro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy.
Anna CargnoniCentro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy.
Andrea PapaitDepartment of Life Science and Public Health, Università Cattolica Del Sacro Cuore, Rome, Italy.
Antonietta R SiliniCentro di Ricerca E. Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy.
Jacopo RomoliDepartment of Life Science and Public Health, Università Cattolica Del Sacro Cuore, Rome, Italy.
Sara FicaiDepartment of Life Science and Public Health, Università Cattolica Del Sacro Cuore, Rome, Italy.
Clara Di MarioImmunology Research Core Facility, Gemelli Science and Technology Park (GSTeP), Fondazione Policlinico Universitario A, Gemelli IRCCS, Rome, Italy.
Elisa GremeseRheumatology and Clinical Immunology Unit, Humanitas Research Hospital, Milan, Italy.
Barbara TolussoImmunology Research Core Facility, Gemelli Science and Technology Park (GSTeP), Fondazione Policlinico Universitario A, Gemelli IRCCS, Rome, Italy.
Ornella ParoliniDepartment of Life Science and Public Health, Università Cattolica Del Sacro Cuore, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by inflammation in the synovial tissue, driven by aberrant activation of both the innate and adaptive immune systems, which can lead to irreversible disability. Despite the increasing therapeutic approaches for RA, only a low percentage of patients achieve sustained disease remission, and the persistence of immune dysregulation is likely responsible for disease recurrence once remission is attained. Cell therapy is an attractive, wide-spectrum strategy to modulate inflammation, and mesenchymal stromal cells (MSC) derived from perinatal tissues provide valuable tools for their use in regenerative medicine, mainly due to their immunomodulatory properties. Several

Indexed as

Autoimmune diseaseFibroblast-like synoviocytesImmune cellsMesenchymal stromal cellsPerinatal cellsRheumatoid arthritis

Identifiers

PMID39811302
PMCPMC11732555

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.