ArticleHeliyon2025
Phthalates toxicity
Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Relationship between oxidative stress and COVID-19 severity: A systematic review and meta-analysis.Journal of advanced veterinary and animal research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Phthalates, a large group of endocrine disruptors, are ubiquitous in the environment and detrimental to human health. This scoping review aimed to summarize the effects of phthalates on laboratory animals relevant to humans, assess toxicity, and analyze mechanisms of toxicity for public health concerns. Methods: Articles were retrieved from Google Scholar, PubMed, ScienceDirect, and Web of Science search engines. The search used the term "toxicity of phthalates Results: Of the 8180 articles screened, 153 met the inclusion criteria. Most of them were published after 2015 (74.50 %). The scoping review showed that DEHP (56.20 %) and DBP (21.57 %) were the most studied phthalates followed by BBP, DiBP, DMP, DEP, BBOP, and DiNP. Scarce data were available on DnOP, DPHP, DPeP, DUDP, DTDP, DMiP, and DiOP. Interestingly, studies of combinations of two or more phthalates were also present. The main laboratory animals employed were rats (48.37 %) and mice (39.87 %), while the least studied were birds (5.22 %) and fish (6.53 %). Most studies related to testicular toxicity (37.60 %), hepatotoxicity (23.53 %), and ovarian toxicity (18.30 %) investigations, while the rest consisted of neurotoxicity (6.88 %), renal toxicity (6.53 %), and thyroid toxicity studies (4.57 %). Studies focused on oxidative stress (34.64 %), apoptosis (22.22 %), steroid hormone deprivation (20.26 %), lipid metabolism disorder (11.76 %), and immunotoxicity (5.88 %) as mechanisms of toxicity. The most commonly used techniques were H&E, RT-qPCR, ROS assay, WB, IHC, ELISA, RIA, TUNEL, TEM, IFM, FCM, and RNA-seq. Conclusions: DEHP and DBP are the most toxic and studied phthalates, while BBP, DiNP, DiBP, DiDP, BBOP, DMP, and DiOP and their combinations require more accurate studies to confirm their toxic effects on human health and mechanisms of action. These will assist policymakers in adopting strategies to minimize public exposure and adverse effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.