Evidence map›Paper›PMID 39811285›Full record

ArticleHeliyon2025

Peripheral blood biomarkers as differential diagnostic markers of disease severity in neonates with hyperbilirubinemia.

Dereje Mengesha Berta, Negesse Cherie, Berhanu Woldu, Aregawi Yalew, Elias Chane, Amare Mekuaninnit, Mebratu Tamir, Zufan Yiheyis, Abiy Ayele Angelo, Zewudu Mulatie and 2 more

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Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Dereje Mengesha BertaDepartment of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Negesse CherieDepartment of Quality Assurance and Laboratory Management, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Berhanu WolduDepartment of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Aregawi YalewDepartment of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Elias ChaneDepartment of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Amare MekuaninnitDepartment of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Mebratu TamirDepartment of Medical Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Zufan YiheyisDepartment of Medical Parasitology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Abiy Ayele AngeloDepartment of Immunology and Molecular Biology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Zewudu MulatieDepartment of medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Adamu KassieDepartment of Medical Laboratory, College of Medicine and Health science, Dilla University, Dilla, Ethiopia.
Bisrat Birke TeketelewDepartment of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Blood biomarkers offers an independent insight for the pathophysiology of hyperbilirubinemia. However, they are not practically used for the differential diagnosis of the hyperbilirubinemia severity. Therefore, the current study aimed to assess the differential diagnostic value of peripheral blood biomarkers with disease severity as an alternative. Methods: A cross-sectional study was done on conveniently selected neonates admitted with hyperbilirubinemia during study period. A 4 ml of venous blood was collected for laboratory analysis. The Sysmex KX-21 cellular analysis and Mindray BS-240 automated chemistry analyzer was used for complete blood count and biochemical analysis, respectively. The data were entered into Epi-data (4.6.0) and analyzed by STATA (14) software. The summary statistics were used. The Kruskal Wallis H tests were utilized to compare median differences between groups. To ascertain the diagnostic value, receiver operator characteristic (ROC) curve analysis was performed. Blood biomarkers score area under curve >.7 was selected as the best discriminative marker. The accepted threshold for statistical significance was set at Result: Current study found that red blood cell (RBC) and absolute lymphocyte count (ALC) can differentiate high-risk from low and intermediate-risk groups. Similarly, they can also stratify low-risk group from the intermediate and high-risk groups. Besides, mean cell volume (MCV), absolute neutrophil count (ANC), neutrophil to lymphocyte (NLR) and platelet to lymphocyte ratio (PLR), can exhibit significant discriminative ability to differentiate high-risk groups from intermediate and low-risk groups as well as low-risk groups from intermediate and high-risk groups. Furthermore, for hemolytic type of hyperbilirubinemia, RBC, Hb (hemoglobin), ALC, NLR, and PLR were found as good diagnostic markers to differentiate high risk group for others. Whereas, for non-hemolytic type of hyperbilirubinemia, MCV, ALC, MPV (mean platelet volume) and NLR were found as good discriminative marker of high-risk group form others. Conclusions: Peripheral blood biomarkers were found as acceptable to good early differential diagnostic marker with significant association to disease severity. Thus, assessing of baseline blood biomarkers can help to differentiate disease severity in neonates with hyperbilirubinemia.

Indexed as

Blood markerHyperbilirubinemiaNeonates

Identifiers

PMID39811285
PMCPMC11730223

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.