ArticleCureus2024
Acute Ventricular Dysfunction After Doxorubicin-Based Induction Therapy for Pediatric Acute Lymphoblastic Leukemia.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Doxorubicin is an important drug used in the treatment of children with acute leukemia, and cardiotoxicity is the most serious complication due to its use. The cardiac dysfunction due to doxorubicin can be acute, early, or late. Echocardiography is a non-invasive tool and can be employed to detect clinical and subclinical cardiac dysfunction and plan treatment strategies accordingly. Materials and methods Twenty-eight children with acute lymphoblastic leukemia were enrolled. Echocardiography was done at baseline and 72 h after induction dose of doxorubicin. Conventional and tissue Doppler imaging parameters were obtained and compared. Results After the induction dose of doxorubicin, both ventricles developed systolic and diastolic dysfunction. Tricuspid annular plane systolic excursion significantly decreased after doxorubicin (20.0±4.95 mm vs. 19.40±4.90 mm). Right ventricular myocardial performance index and isovolumetric relaxation times increased after doxorubicin (0.38±0.08 vs. 0.41±0.08 and 41.4±1.8 ms vs. 43.1±12.6 ms, p<0.05, respectively). Tricuspid E velocity decreased (62.3±8.35 cm/s vs. 60.1±7.34 cm/s, p<0.01) as well as tricuspid E/A ratio after doxorubicin (1.54±0.26 vs. 1.40±0.23, p<0.01). The left ventricular fractional shortening and ejection fraction decreased after doxorubicin (32.1±2.26% vs. 31.4±2.27% and 64.60±4.69% vs. 63.10±4.63%, respectively). Left ventricular myocardial performance index and isovolumetric relaxation times were increased after doxorubicin (0.44±0.05 vs. 0.46±0.06 and 58.6±8.75 ms vs. 60.3±10.1 ms, respectively). Mitral E velocity is reduced (85.6±11.3 cm/s vs. 83±11.9 cm/s) and tricuspid E/A ratio is also reduced after doxorubicin (1.78±0.43 vs. 1.63±0.39). Conclusion Both systolic and diastolic dysfunctions are seen after doxorubicin. Echocardiography should be employed for early diagnosis of clinical and subclinical cardiac dysfunction and timely initiation of management to prevent progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.