Evidence map›Paper›PMID 39811014›Full record

ArticleEuropean heart journal. Imaging methods and practice2025

Three-dimensional assessment of ascending aortic stiffness, motion, and growth in ascending thoracic aortic aneurysm.

Nicasius S Tjahjadi, Taeouk Kim, Prabhvir S Marway, Carlos Alberto Campello Jorge, Timothy J Baker, Constantijn Hazenberg, Joost A van Herwaarden, Himanshu J Patel, C Alberto Figueroa, Nicholas S Burris

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In one paragraph

Article in European heart journal. Imaging methods and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicasius S TjahjadiDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, USA.
Taeouk KimDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, USA.
Prabhvir S MarwayDepartment of Radiology, University of Michigan, 1500 E Medical Center Drive, CVC 5581, Ann Arbor, MI 48109, USA.
Carlos Alberto Campello JorgeDepartment of Radiology, University of Michigan, 1500 E Medical Center Drive, CVC 5581, Ann Arbor, MI 48109, USA.
Timothy J BakerDepartment of Radiology, University of Michigan, 1500 E Medical Center Drive, CVC 5581, Ann Arbor, MI 48109, USA.
Constantijn HazenbergDepartment of Vascular Surgery, University Medical Center Utrecht, Utrecht, Netherlands.
Joost A van HerwaardenDepartment of Vascular Surgery, University Medical Center Utrecht, Utrecht, Netherlands.
Himanshu J PatelDepartment of Cardiac Surgery, University of Michigan, Ann Arbor, USA.
C Alberto FigueroaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, USA.ORCID https://orcid.org/0000-0002-3934-6506
Nicholas S BurrisDepartment of Radiology, University of Michigan, 1500 E Medical Center Drive, CVC 5581, Ann Arbor, MI 48109, USA.ORCID https://orcid.org/0000-0002-5198-4383

Funding

Non-invasive hemodynamic and biomechanic imaging methods for early risk prediction in aortic dissectionR01HL170059 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Nicholas Scott Burris, David Alexander Nordsletten · 2023 to 2026
$2.4M
Vascular Deformation Mapping (VDM) for Automated, 3D Assessment of Thoracic Aortic AneurysmR44HL145953 · NHLBI · IMBIO, LLC · PI BURRIS, NICHOLAS SCOTT, HATT, CHARLES R · 2019 to 2022
$1.5M
NHLBI NIH HHS R01 HL170059NHLBI NIH HHS R44 HL145953
6 · The paper itself

Abstract

Aims: Aortic wall stiffening in ascending thoracic aortic aneurysm (aTAA) is common. However, the spatial and temporal relationships between stiffness, aortic size, and growth in aTAA remain unclear. Methods and results: In this single-centre retrospective study, we utilized vascular deformation mapping to extract multi-directional aortic motion, aortic distensibility, and aortic growth in a multi-planar fashion from multi-phasic ECG-gated computed tomography angiograms. Aortic displacement and stiffness metrics were compared between patients with sporadic ascending aortic dilation (Dilated), individuals without thoracic aortic dilation, and patients with Marfan syndrome. A total of 96 patients were included. Total and axial aortic root motion was significantly decreased in the Dilated group ( Conclusion: Vascular deformation mapping provides multi-level stiffness assessments of the ascending aorta using multi-phasic computed tomography angiography. Ascending aortic stiffening is a spatially heterogeneous process with stiffening tending to increase with degree of regional dilation and age, whereas lower stiffness was associated with faster growth of the mid-ascending aorta in those with sporadic aTAA.

Indexed as

aortaaortic growth rateaortic motionaortic stiffnessthoracic aortic aneurysmvascular deformation mapping

Identifiers

PMID39811014
PMCPMC11726698

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.