Evidence map›Paper›PMID 39810934›Full record

ReviewEClinicalMedicine2025

Beyond bronchial thermoplasty - where to now?

Peter B Noble, David Langton, Chuan T Foo, Bruce R Thompson, Alvenia Cairncross, Michael J Hackmann, Francis Thien, Graham M Donovan

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peter B NobleSchool of Human Sciences, The University of Western Australia, WA, Australia.
David LangtonFaculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia.
Chuan T FooFaculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia.
Bruce R ThompsonSchool of Health Sciences, University of Melbourne, VIC, Australia.
Alvenia CairncrossSchool of Human Sciences, The University of Western Australia, WA, Australia.
Michael J HackmannSchool of Human Sciences, The University of Western Australia, WA, Australia.
Francis ThienFaculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia.
Graham M DonovanDepartment of Mathematics, University of Auckland, Auckland, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the impending 'retirement' of bronchial thermoplasty (BT) for the treatment of patients with asthma, there is much to learn from this real-world experiment that will help us develop more effective future therapies with the same primary target i.e., airway smooth muscle (ASM) remodelling. This viewpoint discusses initial controversy surrounding BT (lack of an effect on forced expiratory volume in 1 s), its underutilisation, and importantly how non-standard diagnostics successfully demonstrated therapeutic response which escaped traditional lung function metrics. It is anticipated that the next iteration of BT (likely in a drug form) will have an overall greater effect on the health care system by virtue of evoking ASM remodelling as a treatable trait, and after appropriately drawing on lessons learned from the ∼fifteen-year BT saga.

Indexed as

Airway smooth muscleAsthmaBronchial thermoplastyStructure-guided therapy

Identifiers

PMID39810934
PMCPMC11731591

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.