ArticleEJIFCC2024
Diagnostic Accuracy of Creatinine-Based Equations for eGFR Estimation in Pakistanis: Evaluation of the European Kidney Function Consortium Equation vs the CKD-EPI Pakistan Equation.
Article in EJIFCC, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Clinical efficacy, safety, and predictors of treatment response to SGLT2 versus DPP-4 inhibitors in type 2 diabetes: a retrospective comparative study.Frontiers in endocrinology · 2026Article
- Performance of the 2021 Estimated Glomerular Filtration Rate CKD-EPI Refit and the European Kidney Function Consortium (EKFC) Formulas.Diagnostics (Basel, Switzerland) · 2025Article
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Authors and funding
6 authors.
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Abstract
Introduction: Chronic Kidney Disease (CKD) is prevalent in Pakistan, necessitating accurate diagnostic methods. This study evaluates the CKD-EPI 2009, CKD-EPI 2021, CKD-EPI Pak, MDRD, and EKFC equations against creatinine clearance (CrCl) to determine their diagnostic accuracy for CKD in the Pakistani population. Methods: n a retrospective cross-sectional study, data from 2,310 participants aged 18-70 were analyzed at The Aga Khan University in Karachi. Serum creatinine (SCr) and CrCl were recorded, and eGFR was calculated using five equations. Statistical analyses compared eGFR equations with CrCl, assessing sensitivity, specificity, and predictive values. Results: EPI-Pak exhibited the highest sensitivity (95.15%) and agreement (94.85%) followed by EPI-2009 and EPI-2021 which showed the closest agreement with CrCl. Bland-Altman plots also indicated that EPI-Pak had the best agreement with CrCl. Discussion: EPI-Pak outperformed other equations in estimating eGFR for the Pakistani population, aligning with previous recommendations for South Asians. EKFC, although highly specific, was less effective overall. Conclusion: EPI-Pak is the most accurate equation for diagnosing CKD in the Pakistani population. Its clinical implementation could improve CKD diagnosis and patient outcomes. Future studies should further validate these findings with larger, diverse samples.
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39810889PMC11726330What OpenQuestion holds
Registered trials
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